Results 111 to 120 of about 3,423,079 (298)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Ablation behaviors of carbon reinforced polymer composites by laser of different operation modes

, 2015
Laser ablation mechanism of Carbon Fiber Reinforced Polymer (CFRP) composite is of critical meaning for the laser machining process. The ablation behaviors are investigated on the CFRP laminates subject to continuous wave, long duration pulsed wave and ...
Wu CW(吴臣武), Huang CG(黄晨光), Wu XQ(吴先前), Wu, CW (reprint author), 15 Bei Si Huan Xi Rd, Beijing 100190, Peoples R China.   +3 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

CO2 Laser Ablation Area Scaling and Redeposition on Flat Polyoxymethylene Targets [PDF]

, 2010
One of the remaining subjects of interest for laser ablation propulsion study is whether special benefits or challenges exist when applying a particularly large or small laser spot area to a target. This subject is of high importance for topics including
Sinko, John Elihu, Eckel, Hans-Albert, Sasoh, Akihiro, Scharring, Stefan, Ogita, Naoya, Röser, Hans-Peter   +5 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Novel evaluation method for electrosurgical ablation by monopolar hot biopsy forceps for colonoscopy

, 2018
Chen Tang,1 Jung Hun Choi2 1Department of Mechanical Engineering, Ohio University Athens, Athens, OH 45701, USA; 2Department of Mechanical Engineering, Georgia Southern University, Statesboro, GA 30459, USA Aim: This study evaluates tissue injury ...
Tang C, Choi JH
core  

Magnetocardiographic demonstration of complex ventricular preexcitation resulting in ablation failure

, 2013
The Wolff-Parkinson-White (WPW) syndrome affects 1 to 3 persons per 1000. Catheter ablation (CA) is nowadays proposed as the preferred therapy (with success in more than 90% of cases) and ECG is the most used non-invasive method for classification and ...
Brisinda, Donatella, Sorbo, Anna Rita, Venuti, Angela, Fenici, Riccardo   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source