Results 91 to 100 of about 55,825 (284)

Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders

open access: yesBrain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Aim The aims of this pilot study were to investigate the levels of biomarkers of microglial/macrophage activation—YKL‐40, sCD163, and sCD14—in patients with neuromyelitis optica spectrum disorder (NMOSD) and determine the possible associations between these biomarkers and Expanded Disability Status Scale (EDSS) scores.
Jinghong Li   +3 more
wiley   +1 more source

PENGUJIAN SIGNIFIKANSI HIPOTESIS NOL DALAM PENELITIAN PSIKOLOGIS

open access: yesBuletin Psikologi, 2015
Walaupun diakui bahwa penerapan pendekatan kualitatif dalam penelitian psikologis cukup terhormat dan layak dilakukan, namun dalam praktek mayoritas penelitian psikologis menggunakan penelitian kuantitatif.
Sumadi Suryabrata
doaj   +1 more source

Quantitative electroencephalographic analysis of delirium tremens development following alcohol‐withdrawal seizure based on a small number of male cases

open access: yesBrain and Behavior, Volume 12, Issue 12, December 2022., 2022
Considering the complications related to alcohol withdrawal syndrome (AWS) such as seizure, delirium tremens and cardiac arrhythmia, it is important to identify the risk of delirium tremens (DT) following AWS and enhance preventive strategies. We observed the characteristics of quantitative electroencephalography in patients with AWS, specifically who ...
Jee‐Eun Yoon   +3 more
wiley   +1 more source

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

open access: yesAngewandte Chemie, EarlyView.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song   +8 more
wiley   +2 more sources

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani   +6 more
wiley   +1 more source

Preparation of gastrodin‐modified dendrimer‐entrapped gold nanoparticles as a drug delivery system for cerebral ischemia–reperfusion injury

open access: yesBrain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Objective This study sought to evaluate the feasibility of multifunctional gastrodin (GAS)‐containing nano‐drug carrier system against cerebral ischemia–reperfusion injury (CIRI). Methods The drug‐loaded nanocomposite (Au‐G5.NHAc‐PS/GAS) with certain encapsulation efficiency (EE) was prepared by physical adsorption method using different ...
Wenqiang Huang   +8 more
wiley   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam   +13 more
wiley   +1 more source

A postpartum enriched environment rescues impaired cognition and oxidative markers in aged mice with gestational inflammation

open access: yesBrain and Behavior, Volume 12, Issue 12, December 2022., 2022
Protein cysteine residues can be oxidized by nitric oxide (NO) to form protein S‐nitrosothiols (SNOs) in a process called S‐nitrosylation. S‐nitrosoglutathione reductase (GSNOR) is a highly specific denitrase for GSNO; it controls the intracellular levels of GSNO and protein SNOs and protects the body from nitrosative stress.
Yu‐Xin Zhang   +9 more
wiley   +1 more source

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