Results 211 to 220 of about 970,796 (266)

Examining iPSC derived motor neuron variability and genome stability monitoring as a solution. [PDF]

Sci Rep
Gaffey F, McCoull D, Vaitone E, Hedges E, Lovejoy C, Yao Z, Wright PD, Mead RJ, Stebbeds W.   +8 more
europepmc   +1 more source

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

Association of Atypical Antipsychotics With Lipid Abnormalities in Adult Patients With Schizophrenia: A Scoping Review. [PDF]

Neuropsychopharmacol Rep
Abavana V, Sadiq S.
europepmc   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Pralsetinib-Induced Lymphocytic Colitis. [PDF]

ACG Case Rep J
Jin MF, Tawfic SS, Wang XJI.
europepmc   +1 more source

Efficacy and Safety of Pirfenidone for Mitigation of Interstitial Lung Abnormalities in COVID-19 Patients: A Meta-Analysis. [PDF]

Can Respir J
Zhang Z, Fang X, Gao J, Sun H, Xu T, Wang J.   +5 more
europepmc   +1 more source

Febrile Neutropenia in the Context of Clozapine-Induced Agranulocytosis (CIA) and Myelodysplastic Syndrome: Importance of a Multidisciplinary Approach. [PDF]

Cureus
Conchinha AF, Pack T, Rodrigues A, Lopes A, Santos A.   +4 more
europepmc   +1 more source

Exploring Pembrolizumab-Induced IM3OS in a Patient With Bladder Cancer. [PDF]

Pharmacol Res Perspect
Chan CC, Lee MJ, Su J, Su JJ.
europepmc   +1 more source

Case Series on Obsessive-compulsive Disorder in Twins: Phenotypic Divergence and Shared Therapeutic Challenges. [PDF]

Indian J Psychol Med
Chouhan A, Rawat M, Sandhu S.
europepmc   +1 more source

Acute amivantamab-induced myocardial injury in a patient with epidermal growth factor receptor-mutant lung cancer: a first case report. [PDF]

Front Oncol
Kaneko S, Dotsu Y, Inoue T, Motokawa T, Yoshimuta T, Mori M, Morikawa T, Honda N, Akagi K, Tomono H, Matsuo M, Taniguchi H, Takemoto S, Mukae H.   +13 more
europepmc   +1 more source