Results 101 to 110 of about 799,164 (305)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Different patterns of white matter degeneration using multiple diffusion indices and volumetric data in mild cognitive impairment and Alzheimer patients [PDF]

, 2012
Alzheimeŕs disease (AD) represents the most prevalent neurodegenerative disorder that causes cognitive decline in old age. In its early stages, AD is associated with microstructural abnormalities in white matter (WM).
Alves, Gilberto Sousa, Gilberto Sousa Alves, Felipe Sudo, Tarik Karakaya, Letice Valente, Laurence O’Dwyer, Viola Oertel-Knöchel, Engelhardt, Eliasz, David Prvulovic, Denise Moreira, Christian Knöchel, O’Dwyer, Laurence, Karakaya, Tarik, Fabian Fuβer, Carlos Eduardo Alves, Fußer, Fabian, Johannes Pantel, Laurence O'Dwyer, Valente, Letice, Jerson Laks, Prvulovic, David, Moreira, Denise, Alves, Carlos Eduardo, Alina Jurcoane, Pantel, Johannes, Oertel-Knöchel, Viola, Laks, Jerson, Eliasz Engelhardt, Sudo, Felipe, Fabian Fußer, Jurcoane, Alina, Knöchel, Christian   +31 more
core   +1 more source

Anatomical Abnormalities in Multiple Permanent Teeth [PDF]

Journal of Clinical and Diagnostic Research, 2015
Karthik Venkataraghavan, Vidhi Shah, Prashant Choudhary, Krishna Trivedi, Shalin Shah   +4 more
doaj   +1 more source

NF1 with Multiple Cardiac Structural Abnormalities Leading to Cerebral Infarction

Diagnostics
Background/Objectives: Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder driven by mutations in the NF1 gene, whose pathogenesis centers on the loss of neurofibromin function and subsequent hyperactivation of the RAS/MAPK pathway. Notably,
Jingwei Ye, Yiyi Jiang, Hanmin Wang, Dan Wang   +3 more
doaj   +1 more source

Prenatal diagnosis and genetic analysis of fetal akinesia deformation sequence and multiple pterygium syndrome associated with neuromuscular junction disorders: A review

Taiwanese Journal of Obstetrics & Gynecology, 2012
Fetal akinesia deformation sequence is a clinically and genetically heterogeneous disorder characterized by a variable combination of arthrogryposis, fetal akinesia, intrauterine growth restriction, developmental abnormalities such as cystic hygroma ...
Chih-Ping Chen
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Trisomy 16 in a mid-trimester IVF foetus with multiple abnormalities [PDF]

, 2004
An 18 week foetus with multiple system abnormalities was found to have full trisomy 16. This appears to be only the third reported case surviving into mid-gestation; typically, this common aneuploidy dies post-implantation.
Mohammed, S, Seller, M J, Kumar, A, Fear, C   +3 more
core   +1 more source

Flower-Like Plasma Cell Nuclei in Multiple Myeloma

Turkish Journal of Hematology, 2021
Abibatou Sall, Moussa Seck, Diama Samb, Blaise Félix Faye, Macoura Gadji, Saliou Diop, Awa Oumar Touré   +6 more
doaj   +1 more source

Experience of the diagnosis and observation of a child with wolf-hirschhorn syndrome

Zdorovʹe Rebenka, 2017
Modern data about the causes, course peculiarities, principles of diagnosis and symptomatic treatment of Wolf-Hirshhorn syndrome are given in the article. The description of own clinical case is presented.
L.V. Besh, O.I. Matsyura, G.V. Bulak, V.N. Chyrun, V.P. Bobyk, D.V. Stakhnyak   +5 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source