Results 41 to 50 of about 7,398,089 (304)

Daclizumab reverses intrathecal immune cell abnormalities in multiple sclerosis

Annals of Clinical and Translational Neurology, 2015
Novel treatments such as natalizumab and fingolimod achieve their therapeutic efficacy in multiple sclerosis (MS) by blocking access of subsets of immune cells into the central nervous system, thus creating nonphysiological intrathecal immunity.
Yen-Chih Lin, Paige N. Winokur, A. Blake, Tianxia Wu, E. Romm, B. Bielekova   +5 more
semanticscholar   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Exploring the Impact of Cytogenetic Abnormalities on Treatment Responses and Survival Outcomes in Multiple Myeloma: A Single-Centre Experience of 13 Years of Follow-Up

Biomedicines
(1) Background: The introduction of novel therapies has led to a considerable evolution in the management of Multiple Myeloma, and chromosomal abnormalities predict the success of treatment.
Mehmet Ali Kazgı, Ertugrul Bayram, Tolga Kosecı, Burak Mete, Tugba Toyran, Melek Ergin, Ismail Oguz Kara   +6 more
doaj   +1 more source

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

Nature, 2017
Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring.
Sangdoo Kim, Hyunju Kim, Y. S. Yim, Soyoung Ha, K. Atarashi, T. G. Tan, R. Longman, K. Honda, D. Littman, Gloria B. Choi, Jun R. Huh   +10 more
semanticscholar   +1 more source

Fontan Circulation Associated Organ Abnormalities Beyond the Heart, Lungs, Liver, and Gut: A Systematic Review

Frontiers in Cardiovascular Medicine, 2022
IntroductionPatients with a Fontan circulation are at risk for sequelae of Fontan physiology during follow-up. Fontan physiology affects all organ systems and an overview of end-organ damage is needed.MethodsWe performed a systematic review of ...
Evi Ritmeester, Veerle A. Veger, Jelle P. G. van der Ven, Jelle P. G. van der Ven, Gabrielle M. J. W. van Tussenbroek, Carine I. van Capelle, Floris E. A. Udink ten Cate, Willem A. Helbing, Willem A. Helbing   +8 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS

International Journal of Endocrinology, 2019
Background. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs.
Mingqun Deng, Han Wu, Miao Yu, Yi Tian, Yuxiu Li, Xinhua Xiao   +5 more
doaj   +1 more source

Voxel-Based Meta-Analysis of Gray Matter Abnormalities in Multiple System Atrophy

Frontiers in Aging Neuroscience, 2020
Purpose: This study aimed to identify consistent gray matter volume (GMV) changes in the two subtypes of multiple system atrophy (MSA), including parkinsonism subtype (MSA-P), and cerebellar subtype (MSA-C), by conducting a voxel-wise meta-analysis of ...
Junyu Lin, Xinran Xu, Yanbing Hou, Jing Yang, Huifang Shang   +4 more
doaj   +1 more source

A cross‐sectional study on the prevalence of electrolyte abnormalities in multiple trauma patients in Hamedan, Iran

Health Science Reports, 2021
Introduction Evaluation of electrolyte status and homeostasis is one of the most important components of evaluation and treatment of critically ill patients, especially those with multiple trauma.
Bareza Rezaei, Einaz Ramazani, Rahimpour Amiri, Zahra Sanaei   +3 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source