Results 41 to 50 of about 1,171,990 (253)

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. [PDF]

, 2017
Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology.
Brumback, AC, Davatolhagh, F, Ellwood, IT, Iafrati, J, Kjaerby, C, Lee, AT, Nagaraj, S, Patel, T, Robinson, S, Sohal, VS   +9 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Co-Occurrence of Multiple Endocrine Abnormalities Induced by the DIHS/DRESS

International Journal of Endocrinology, 2019
Background. Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe adverse reaction caused by specific drugs.
Mingqun Deng, Han Wu, Miao Yu, Yi Tian, Yuxiu Li, Xinhua Xiao   +5 more
doaj   +1 more source

Prothrombotic coagulation abnormalities in patients with newly diagnosed multiple myeloma

Haematologica, 2007
Prothrombotic coagulation abnormalities were analyzed in patients with untreated multiple myeloma. Increases in factor VIII, in von Willebrand factor and a decrease in protein S were observed and these changes were strongly associated with disease stage.
Johannes J.A. Auwerda, Pieter Sonneveld, Monica P.M. de Maat, Frank W.G. Leebeek   +3 more
doaj   +1 more source

Fontan Circulation Associated Organ Abnormalities Beyond the Heart, Lungs, Liver, and Gut: A Systematic Review

Frontiers in Cardiovascular Medicine, 2022
IntroductionPatients with a Fontan circulation are at risk for sequelae of Fontan physiology during follow-up. Fontan physiology affects all organ systems and an overview of end-organ damage is needed.MethodsWe performed a systematic review of ...
Evi Ritmeester, Veerle A. Veger, Jelle P. G. van der Ven, Jelle P. G. van der Ven, Gabrielle M. J. W. van Tussenbroek, Carine I. van Capelle, Floris E. A. Udink ten Cate, Willem A. Helbing, Willem A. Helbing   +8 more
doaj   +1 more source

Classification of neurological abnormalities in children with congenital melanocytic naevus syndrome identifies magnetic resonance imaging as the best predictor of clinical outcome [PDF]

, 2015
Background: The spectrum of central nervous system (CNS) abnormalities described in association with congenital melanocytic naevi (CMN) includes congenital, acquired, melanotic and nonmelanotic pathology.
Atherton, D, Aylett, SE, Chong, WK, Kinsler, VA, Thompson, DJ, Waelchli, R   +5 more
core   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Deep Lesion Graphs in the Wild: Relationship Learning and Organization of Significant Radiology Image Findings in a Diverse Large-scale Lesion Database

, 2018
Radiologists in their daily work routinely find and annotate significant abnormalities on a large number of radiology images. Such abnormalities, or lesions, have collected over years and stored in hospitals' picture archiving and communication systems ...
A Esteva, A Teramoto, AAA Setio, Geert Litjens, Guohui Wei, Hayit Greenspan, HC Shin, Helen Hong, Hoo-Chang Shin, JANE BROMLEY, JH Moltz, Jinzheng Cai, Johannes Hofmanninger, Jonathan Krause, Jose Ramos, JS Silva, Ke Yan, Kenneth Clark, M Everingham, M Sevenster, Nima Tajbakhsh, Tsung-Yi Lin, Zhe Wang, Zhongyu Li   +23 more
core   +1 more source