Results 71 to 80 of about 799,164 (305)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Familial Cancers of Head and Neck Region [PDF]

Journal of Clinical and Diagnostic Research, 2017
Cancers that occur in families more often than would be expected by chance are termed as familial cancers. They occur due to an inherited genetic mutation and account for 5%-10% of all cancers.
Reshma Venugopal, Radhika Manoj Bavle, Paremala Konda, Sudhakara Muniswamappa, Soumya Makarla   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Electrocardiographic Pattern and Cardiovascular Risk Factors among University Students in Dar es salaam – Tanzania [PDF]

, 2012
Abnormal resting electrocardiogram (ECG) findings have been strongly associated with subsequent increase in all cause CAD and CVD mortality. The abnormalities are defined as either major or minor based on the different criteria.
Kimambo, D.C, Kimambo, Delilah Charles
core  

Brain structural and neurofunctional correlates of liability to psychosis : a multimodal neuroimaging approach [PDF]

, 2011
Schizophrenia is one of the most debilitating and still not entirely understood mental diseases. Improvements in the treatment came hand in hand with an introduction of antipsychotics and thus with better understanding of neurobiology underlying its ...
Smieskova, Renata
core   +1 more source

Cytogenetic anomalies in Multiple Myeloma patients:A single center study

Genetics & Applications, 2019
Conventional karyotyping in the patients with Multiple myeloma (MM) is very important. Because chromosomal abnormalities which detected in these patients have diagnostic and prognostic value.
Süreyya Bozkurt, Yahya Büyükaşık, Haluk Demiroğlu, Elifcan Aladağ Karakulak, Müfide Okay, Ayşe Karataş, Salih Aksu, İbrahim Haznedaroğlu, Nilgün Sayınalp, Osman Özcebe, Hakan Göker   +10 more
doaj  

Long-term prognostic impact of chromosome 1 abnormalities in newly diagnosed multiple myeloma patients: a monocentric study

Annals of Hematology
The presence of chromosome 1 abnormalities in multiple myeloma (MM) has been included in the more recent prognostic staging system; however, the prognostic role of chromosome 1 abnormalities remains controversial. Thus, in this study we have investigated
Nicolas Thomas Iannozzi, Gabriella Sammarelli, Andrea Poletti, Giannalisa Todaro, Matia Bernardi, Matteo Scita, Anna Benedetta Dalla Palma, Vincenzo Raimondi, Oxana Lungu, Eleonora Carboni, Stefania Ricci, Camilla Sitzia, Mattia Dessena, Rosanna Vescovini, Denise Toscani, Paola Storti, Nicola Giuliani   +16 more
doaj   +1 more source

Comparison of Intraspinal Abnormalities Prevalence in Congenital Scoliosis

JBJS Open Access
Background:. The increasing utilization of magnetic resonance imaging has facilitated the detection of intraspinal abnormalities in congenital scoliosis (CS) caused by hemivertebra.
Li Jie, MD, PhD, Chen Chunxiao, MS, Qin Xiaodong, MD, PhD, Hu Zongshan, MD, PhD, Qiao Jun, MD, PhD, Mao Saihu, MD, PhD, Shi Benlong, MD, PhD, Qiu Yong, MD, PhD, Zhu Zezhang, MD, PhD, Liu Zhen, MD, PhD   +9 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A cross‐sectional study on the prevalence of electrolyte abnormalities in multiple trauma patients in Hamedan, Iran

Health Science Reports, 2021
Introduction Evaluation of electrolyte status and homeostasis is one of the most important components of evaluation and treatment of critically ill patients, especially those with multiple trauma.
Bareza Rezaei, Einaz Ramazani, Rahimpour Amiri, Zahra Sanaei   +3 more
doaj   +1 more source