Results 41 to 50 of about 128,758 (276)

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Septic induced Abortion

Journal of University Medical & Dental College, 2020
Unsafe abortion is one of the major health problems in developing countries and a serious concern for women in their reproductive years. Unsafe abortion mostly ending up in septic induced miscarriages, septicemia and septic shock is a leading cause of ...
Mubashra Naz
doaj  

New Evidence on Induced Abortion in Tehran, Iran: Rates, Causes, and Changes [PDF]

Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān, 2018
Introduction: Awareness of the incidence of abortion in Iran is essential to promoting maternal health. Therefore, it is of paramount importance to estimate the rate of induced abortion.
Amir Erfani, Javad Shojaei
doaj   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Study of the Frequency, Causes and Methods of Elective Abortion and Demographic Characteristics of Women Referring to Alavi Educational and Medical Center, Ardabil 2022-2023 [PDF]

Journal of Ardabil University of Medical Sciences
Background: Elective abortion is one of the factors affecting the decline in population growth and fertility rates and is a complex issue in the field of reproductive health.
Narges Karimi, Shahla Farzipour, Fatemeh Mirershadi, Samira Shahbazzadegan   +3 more
doaj  

Induced abortion and future use of IVF treatment; A nationwide register study.

PLoS ONE, 2019
OBJECTIVE:In this nationwide study we assessed the use and factors associated with future in vitro fertilization (IVF) treatment after induced abortion.
Jaana Männistö, Maarit Mentula, Aini Bloigu, Mika Gissler, Oskari Heikinheimo, Maarit Niinimäki   +5 more
doaj   +1 more source

Endometrial Assembloid Model Reveals Endometrial Gland Development Regulation by Estradiol‐Driven WNT7B Suppression

Advanced Science, EarlyView.
This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li, Yanjie Guo, Jianlin Li, Yimeng Li, Leqian Lin, Hoi Kit Matthew Leung, Qingqing Zhang, Kai‐Fai Lee, Ka‐Wang Cheung, Ernest H. Y. Ng, William S. B. Yeung, Philip C. N. Chiu, Cheuk‐Lun Lee   +12 more
wiley   +1 more source

Prevalence and determinants of repeat induced abortion in Ethiopia: A systematic review and meta-analysis

Heliyon, 2023
Introduction: Repeat-induced abortion is the termination of pregnancy for more than one time using drugs or surgical intervention before the fetus reaches the age of viability. This study aimed to estimate the pooled prevalence of repeat-induced abortion
Kenbon Seyoum, Sheleme Mengistu
doaj   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source