Results 61 to 70 of about 240,112 (293)

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

A Closer Look at Rape Myth Beliefs Among University Students: Comparisons and Correlates Based on Field and Stage of Study, Victimisation Experiences, Demographics and Psychological Traits

Behavioral Sciences &the Law, EarlyView.
ABSTRACT Disproportionate rates of sexual violence occur among university students, with rape culture and misconceptions about consent prevalent. To comprehensively examine rape myth beliefs among different student groups, 417 UK University students enrolled on courses in four distinct disciplinary areas; social sciences (n = 131), applied sciences (n =
Dominic Willmott, Mairi Johnston, B. Kennath Widanaralalage, Dara Mojtahedi, Daniel Boduszek, Danielle McDermott, Gillian Kirkman   +6 more
wiley   +1 more source

Maternal and Neonatal Complications Associated with Breast Cancer Systemic Treatments—A VigiBase Disproportionality Analysis Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy‐associated breast cancer (PrBC) presents therapeutic challenges. Understanding maternal–fetal safety of systemic anticancer therapies is critical. We performed a case/non‐case disproportionality analysis using the WHO global pharmacovigilance database up to January 2024, to evaluate maternal–fetal outcomes associated with breast cancer (BC ...
Rayan Kabirian, Floriane Jochum, Elise Dumas, Florence Coussy, Kevin Bihan, Bénédicte Lebrun‐Vignes, Barbara Pistilli, Marc‐Antoine Benderra, Lise Selleret, Laurent Chouchana, Fabien Reyal, Anne‐Sophie Hamy, Paul Gougis   +12 more
wiley   +1 more source

Serum and endometrial organic acid profile in women with missed abortion

Фундаментальная и клиническая медицина, 2019
Aim. To determine the role of organic acids in the pathogenesis of missing abortion.Materials and Methods. To analyze the endometrial organic acid content, we applied high performance liquid chromatography.
I. M. Ordiyants, S. S. Barabasheva, A. M. Savicheva   +2 more
doaj   +1 more source

Maternal Dipyrone Exposure and Risk of Major Congenital Malformations, Adverse Perinatal and Postnatal Outcomes: A Population‐Based Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Pain and fever are common in pregnancy. Dipyrone is widely used in Europe, Latin America, and parts of Asia, but is banned in other countries due to concerns about agranulocytosis. Evidence on its safety in pregnancy remains limited and inconsistent. This study aimed to evaluate whether maternal dipyrone use during the first‐ and third‐trimesters is ...
Itamar Ben Shitrit, Daphna Idan, Ariel Avraham Hasidim, Tal Michael, Amalia Levy, Gali Pariente, Eitan Lunenfeld, Sharon Daniel   +7 more
wiley   +1 more source

Predictive value and mediating effect analysis of the AHR-ARNT-CYP1A1 axis for missed abortion related to polycyclic aromatic hydrocarbons exposure

Scientific Reports
This study aimed to determine the predictive value of aryl hydrocarbon receptor (AHR) signaling pathway genes, and to detect the mediating effect of AHR that may mediate the influence of polycyclic aromatic hydrocarbons (PAHs) on missed abortion.
Jiuru Cao, Mei Han, Fuxing Li, Jiayu Zhang, Jingru Ji, Junni Wei   +5 more
doaj   +1 more source

Phase I Evaluation of Siltartoxatug, a First‐in‐Class Anti‐Tetanus Monoclonal Antibody: Safety, Pharmacokinetics and Pharmacodynamics in Healthy Australian and Chinese Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Siltartoxatug, a first‐in‐class monoclonal antibody targeting tetanus toxin for post‐exposure prophylaxis, was evaluated in two phase I trials in Australian and Chinese healthy adults. In these randomized, double‐blind, placebo‐controlled, dose‐escalation studies, participants received a single intramuscular injection of siltartoxatug (10–250 μg/kg) or
Xinyu Liu, Zhigang Liu, Xiaohu Kuang, Yueming Wang, Xiaoyi Liu, Jiyuan Ding, Xia Zhou, Xin Zhou, Qianyu Liang, Meizhuo Zhang, Hao Zhao, Qingqing Tan, Weihong Zheng, Huaxin Liao, Charlotte Lemech, Wanmei Wang   +15 more
wiley   +1 more source

Everyone Knows It's a Hoax: The Role of Perceived Descriptive Norms in Conspiracy Beliefs

European Journal of Social Psychology, EarlyView.
ABSTRACT People's belief in conspiracy theories is shaped by social influence processes. This contribution investigated these processes in six studies (total N = 2906) by examining the role of descriptive norms, that is, the perception that others endorse conspiracy theories.
Jan‐Willem van Prooijen, Paul K. Bergmann, Vladimira Čavojová, Jakub Šrol   +3 more
wiley   +1 more source

Serum Endocan Levels in Patients Diagnosed With Missed Abortion: A Case-control Study

Clinical and Experimental Obstetrics & Gynecology
Background: This case-control study explored circulating endothelial cell-specific molecule-1 (endocan), a marker of vascular impairment, in women diagnosed with missed abortion and compared the findings with those of healthy pregnant ...
Nurcan Yoruk, Saime Ozbek Sebin
doaj   +1 more source

The Efficacy of Vaginal Misoprostol in Treatment of Missed Abortions

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2005
Introduction: Missed Abortion is a important obstetric and gynecology complication because of its serious outcomes such as DIC, infection, shock, hemorrhage & death. There are various medical and surgical methods for treatment of missed abortion. Medical
M Tabatabaei, R Dehghani Firooz-abadi, T Faraj khoda, MA Karimzadeh-Maibodi, R Mirmohammadi-Maibodi   +4 more
doaj