Results 111 to 120 of about 215,387 (315)

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Induced abortion potential among Indian women [PDF]

Information on abortion is limited and inaccurate especially in the developing world, which has led to several speculations on the prevalence of abortion in this region. A rise in prevalence of abortion is mostly accounted for in terms of increase in the
S. Irudaya Rajan, Mala Ramanathan, U.S. Mishra   +2 more
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A Modular Mechanistic In Silico Model for In Vitro Transcription Process Yield and Product Quality Prediction

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In vitro transcription (IVT) plays a critical role in the manufacture of mRNA vaccines and therapeutics. Optimizing mRNA yield and ensuring product quality, such as capping efficiency and integrity, are essential but mechanistically complex. This study presents a modular mechanistic model of the IVT process to advance scientific understanding ...
Keqi Wang, Keilung Choy, Eli Reiser, Jinxiang Pei, Hua Zheng, Aparajita Dasgupta, Fuqiang Cheng, Guogang Dong, Bhanu Chandra Mulukutla, Joshua Mannheimer, Carolyn Huang, Hooman Farsani, Wei Xie   +12 more
wiley   +1 more source

Socio-Economic Determinants Of Abortion Rates [PDF]

Abortion rates are increasing all around the world, especially for young women. Our proposals for public policies to reduce unwanted pregnancies are based on an analysis of the socio-economic determinants of abortion rates.
Gil-Lacruz, Ana Isabel, Bernal Cuenca, Estrella, Gil Lacruz, Marta   +2 more
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Tetraspanin‐ESCRT sorting drives miR‐29b packaging into extracellular vesicles to reverse fibrosis in intrauterine adhesions

BMEMat, EarlyView.
MiR‐29b is enriched in extracellular vesicles (EVs) via a tetraspanin transporter‐dependent endocytosis and sorting complex required for the endosomal transport (ESCRT)‐dependent pathway. These EVs target the 3′ untranslated region (3′UTR) of TGFB2, thereby inhibiting the TGF‐β/Smad3 signaling pathway and repairing endometrial damage in intrauterine ...
Lihao Chen, Jianfeng Wu, Shunhan Zhang, Siqi Huang, Yingjun Xie, Hongda Chen, Yinghong Yang, Lan Xiao, Ding Wang, Keke Wu, Xiaofang Sun   +10 more
wiley   +1 more source

Endometrial expression of T-cell immunoreceptor with Ig and ITIM domains and cluster of differentiation 155: A case-control study of a novel immunomodulatory axis in endometriosis

International Journal of Reproductive BioMedicine
Background: Endometriosis is a chronic inflammatory disorder affecting about 10% of females in their reproductive years, characterized by endometrial tissue growing outside the uterus.
Reyhane Nematollahi, Morteza Samadi, Fateme Montazeri, Seyed Mehdi Kalantar, Ali Shams   +4 more
doaj   +1 more source

Abortion surveillance annual summary 1972

This report summarizes information received from collaborators in state health departments, hospitals, and other pertinent sources. It is intended primarily for their use, but may be of interest to others with responsibility for family planning ...

core  

State Abortion Rates: The Impact of Policies, Providers, Politics, Demographics, and Economic Environment [PDF]

This paper uses data on abortion rates from 1974-88, to estimate two-stage least squares models with fixed state and year effects. The results indicate that implementing restrictions on Medicaid funding for abortion results in lower aggregate abortion ...
Rebecca A. London, Christine C. George, Rebecca M. Blank   +2 more
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Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Impact of platelet-rich plasma at different concentrations on genes of apoptotic pathway and differentiation of stem cells in cyclophosphamide-induced ovarian failure in a mouse model: An experimental study

International Journal of Reproductive BioMedicine
Background: Platelet-rich plasma (PRP), a new therapeutic technique, has the potential to regenerate failing ovarian tissue and alleviate symptoms in patients with premature ovarian failure (POF).
Gholamreza Fotoohi-Ardakani, Nasrin Ghasemi, Azam Hassanpour Dehnavi, Ali Dadbinpour, Marzieh Lotfi   +4 more
doaj   +1 more source