Results 91 to 100 of about 112,084 (259)

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

open access: yesMovement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson   +5 more
wiley   +1 more source

Case study of microarthropod communities to assess soil quality in different managed vineyards [PDF]

open access: yesSOIL, 2015
Land use influences the abundance and diversity of soil arthropods. The evaluation of the impact of different management strategies on soil quality is increasingly sought, and the determination of community structures of edaphic fauna can represent an ...
E. Gagnarli   +9 more
doaj   +1 more source

SU(3)_flavor analysis of two-body weak decays of charmed baryons [PDF]

open access: yes, 1997
We study two-body weak decays of charmed baryons \Lambda_c and \Xi_c into an octet or decuplet baryon and a pseudoscalar meson employing the SU(3) flavor symmetry.
F. Buccella   +25 more
core   +2 more sources

Bilateral Transcranial Doppler Monitoring During Neonatal Cardiac Surgery; Guidance for Clinical and Scientific Use

open access: yesPediatric Anesthesia, EarlyView.
ABSTRACT Introduction Neonates undergoing cardiac surgery face a high risk of neurological injury and neurodevelopmental complications. Transcranial Doppler monitoring is used and validated in adults to measure cerebral blood flow and can provide valuable insights into cerebral perfusion in neonates.
B. V. Martherus   +11 more
wiley   +1 more source

Merging Belief Propagation and the Mean Field Approximation: A Free Energy Approach [PDF]

open access: yes, 2012
We present a joint message passing approach that combines belief propagation and the mean field approximation. Our analysis is based on the region-based free energy approximation method proposed by Yedidia et al.
Badiu, Mihai-Alin   +4 more
core   +3 more sources

ABP y tecnología en educación infantil

open access: yes, 2017
Los procesos de ensenanza y aprendizaje en la etapa de Educacion Infantil se ven especialmente favorecidos con el enfoque metodologico Aprendizaje Basado en Proyectos (ABP) y as Tecnologias del Aprendizaje y la Comunicacion (TAC), entendidas como ...
A. Martínez   +2 more
semanticscholar   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

open access: yesThe Journal of Pathology, EarlyView.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou   +3 more
wiley   +1 more source

Strong impact of sulfotransferases on DNA adduct formation by 4‐aminobiphenyl in bladder and liver in mice

open access: yesCancer Medicine, 2018
Bladder cancer risk is 3‐4 times higher in men than women, but the reason is poorly understood. In mice, male bladder is also more susceptible than female bladder to 4‐aminobiphenyl (ABP), a major human bladder carcinogen; however, female liver is more ...
Yun Li   +7 more
doaj   +1 more source

AUTOMATIC POURING WITH STOPPER-CONTROLLED POURING MECHANISMS

open access: yesЛитьë и металлургия, 2010
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A. Wolfgang
doaj   +1 more source

Structural Modeling and Dynamics of the Full‐Length Homer1 Multimer

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Homer proteins are modular scaffold molecules that constitute an integral part of the protein network within the postsynaptic density. Full‐length Homer1 forms a large homotetramer via a long coiled coil region, and can interact with proline‐rich target sequences with its globular EVH1 domain.
Zsófia E. Kálmán   +9 more
wiley   +1 more source

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