Results 81 to 90 of about 93,253 (280)

A Concept of the Effective Surface Profile to Predict the Roughness Parameters of Worn Surface

Frontiers in Mechanical Engineering, 2019
A new concept of the effective surface profile is proposed to facilitate the prediction of the worn surface texture at sliding friction. The effective surface profile is a 2D height characteristic that consists of the asperities of surface superimposed ...
Alexander Kovalev, Zhang Yazhao, Cao Hui, Yonggang Meng   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Wear of Hard Dental Tissues and Methods of its Evaluation

Česká Stomatologie a Praktické Zubní Lékařství, 2018
Background: In addition to tooth decay, that is the most common disease of hard dental tissues, the dentist often encounters with so-called noncarious lesions.
P. Holík, Y. Morozova
doaj   +1 more source

Analisis Abrasi Terhadap Pergeseran Tepi Pantai Dengan Digital Shorline Analisis System (DSAS)

Teras Jurnal: Jurnal Teknik Sipil
Abstrak   Pantai Cahaya Negeri, Kecamatan Lemong Kabupaten Pesisir Barat mengalami abrasi signifikan, berdampak pada pergeseran tepi pantainya. Tujuan penelitian adalah untuk mengkaji, mengidentifikasi dampak pergeseran tepi pantai oleh abrasi periode ...
alim yulianto, Ahmad Zakaria, Dyah Indriana Kusumastuti   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

Tribological Behavior of Glycerol/Water-Based Magnetorheological Fluids in PMMA Point Contacts

Frontiers in Materials, 2019
Comprehension of the tribological behavior of magnetorheological fluids is crucial for many applications, in particular for those related with high quality surface finishing.
Wagner O. Rosa, Fernando Vereda, Juan de Vicente   +2 more
doaj   +1 more source