Results 61 to 70 of about 50,291 (237)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Abrasion-corrosion of downhole drill tool components
, 2008 The present work is a Schlumberger funded PhD project entitled ‘Abrasion-corrosion of downhole drill tool components’. The objective of this project was to replicate the wear-corrosion mechanisms of tungsten carbide (WC)-based hardmetals and coatings ...
Thakare, Mandar Rajiv
core +2 more sources
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Multiphase-based predictive framework construction of abrasive wear performance in C–V–Cr–Mo alloys
Journal of Materials Research and TechnologyAbrasive wear persists as the dominant failure mechanism in crushing equipment, driving the demand for predictive models to guide wear-resistant alloy design and equipment lifespan assessment.
Tao Jiang +9 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
A study of the wear process related to twin-screw extruders [PDF]
, 1996 Extruders are used in a wide range of process industries and high reliability is essential if cost effective manufacturing is to be maintained. A critical part of twin-screw extruders is the barrel that must withstand many different wear and corrosion ...
Grigoroudis, K.
core +4 more sources
Journal of Materials Research and TechnologyAn 18Ni(200) maraging steel ingot was prepared using vacuum smelting, and after undergoing forging and two solution treatments at 1000 °C + 800 °C, the effect of aging treatment at 350–600 °C on the evolution of the microstructure and mechanical ...
Jikang Hu +5 more
doaj +1 more source
Mass Distribution of Particulate Matter Produced During Abrasion af Asphalt Mixtures in Laboratory
Communications, 2016 Non-exhaust emissions of particulate matter from road traffic can come from abrasion of vehicle parts (tyres, brake linings, clutch and bodywork) or from pavement surface abrasion and also from resuspension of dust. A differentiation between PM emissions
Dasa Fullova +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source