Results 81 to 90 of about 2,671,588 (381)
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Estimation of the wear rate associated with ball mill of Mahd Ad Dahab Gold Mine, Saudi Arabia (KSA) [PDF]
, 2018 Purpose. This study aims to estimate the wear of the middle chrome grinding balls in both dry and wet grinding media. The selected ball mill for this study is located at Mahd Ad Dahab Gold Mine, Saudi Arabia. Methods.
Abdelhaffez, G
core +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Erosion-corrosion behaviour of Zirconia WC-6Co, WC-6Ni and SS316 [PDF]
, 2015 The current study investigates a ceramic, two cermets and a metal under solid-liquid impingement with 3.5% NaCl and 150mg/l hydraulic fracturing sand at two extreme angles of impact, 90° and 20°.
Andrews, N. +3 more
core
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
Highly Abrasion-resistant and Long-lasting Concrete [PDF]
, 2019 Studded tire usage in Alaska contributes to rutting damage on pavements resulting in high maintenance costs and safety issues. In this study binary, ternary, and quaternary highly-abrasion resistant concrete mix designs, using supplementary cementitious ...
Liu, Jenny, Murph, Diane
core
A high-precision liDAR-based method for surveying and classifying coastal notches [PDF]
, 2018 Formation of notches is an important process in the erosion of seaside cliffs. Monitoring of coastal notch erosion rate and processes has become a prime research focus for many coastal geomorphologists.
Antunes +9 more
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source