The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Tongue squamous cell carcinoma (TSCC) often develops therapeutic resistance. Metabolic reprogramming, particularly the glycolysis/lactate/histone lactylation axis, is a critical driver of tumor progression and therapy resistance. This study investigated the anti‐tumor mechanism of Rhaponticin (Rha), focusing on the metabolic/epigenetic axis ...
Yuan Wu +7 more
wiley +1 more source
Microstructure and Processing Performance of Brazed Diamond Micro-Powder Grinding Wheel with Ni-Based Filler Alloy. [PDF]
Materials (Basel)Wang S, Xiao H, Xiao B.
europepmc +1 more source
KAT8‐Low Osteosarcoma Suppresses Cisplatin Sensitivity via H4K16ac‐Mediated Cell Apoptosis
Med Research, EarlyView.The scientific significance of this study is highlighted below: (1) Data mining and clinical discovery: These findings establish a direct clinical link between the KAT8–H4K16ac axis and chemotherapy response in osteosarcoma. (2) Multi‐omics and machine‐learning integration: We integrated proteomics and CUT&Tag multi‐omics to elucidate how chromatin ...
Zhenqun Zhao +12 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley +1 more source
Machine learning-assisted evolutionary optimization of hole quality and surface integrity in abrasive waterjet drilling of polycarbonate. [PDF]
Sci RepChandar JB +5 more
europepmc +1 more source
Tool Wear and Surface Finish in AISI 304 Stainless Steel Dry Turning with Cermet Inserts. [PDF]
Materials (Basel)Magalhães LC +3 more
europepmc +1 more source
Study on Water-Jet-Guided Laser-Ultrasonic Grinding Hybrid Processing Technology for SiC<sub>f</sub>/SiC Composite Materials. [PDF]
Materials (Basel)Yu G, Zhang D, Pei X, Yang F.
europepmc +1 more source
High-Efficiency and Low-Defect Removal Mechanism of Silicon Carbide Using Center-Inlet Computer-Controlled Polishing. [PDF]
Micromachines (Basel)Lei P +7 more
europepmc +1 more source
Machinability Enhancement of Ti6Al7Nb Biomedical Alloy Through MWCNT-Nanofluid MQL and Vortex Tube-Assisted Side Milling. [PDF]
Materials (Basel)Khan AM +7 more
europepmc +1 more source
Grinding-Electrode-Assisted Short Electric Arc Machining of GH4099: A Composite Approach to Surface Integrity. [PDF]
Materials (Basel)Wang B +5 more
europepmc +1 more source