Results 21 to 30 of about 10,483 (259)

Study on high quality surface finishing technology of pre-spinning nozzle in additive manufacturing

Xibei Gongye Daxue Xuebao, 2021
Through the simulation of abrasive flow in the inner cavity of the superalloy pre-spinning nozzle made by additive manufacturing, the special abrasive polishing tool is optimized and the surface polishing technology of the inner cavity of typical ...

doaj   +1 more source

Optimization of the Morphology of the Removal Function for Rotating Abrasive Water Jet Polishing

Micromachines, 2023
Abrasive water jet polishing has significant advantages in the manufacturing of complex optical components (such as high-slope optical component cavities) that require high-precision manufacturing.
Guipeng Tie, Zhiqiang Zhang, Bo Wang, Ci Song, Feng Shi, Wanli Zhang, Hailun Si   +6 more
doaj   +1 more source

The Preparation and Performance Analysis of a Cr₂O₃ Gel Abrasive Tool for Sapphire Substrate Polishing

Lubricants, 2022
In order to solve the problem of the agglomeration of abrasives in traditional hot-pressing abrasive tools, this paper proposes a chromium oxide (Cr2O3) gel abrasive tool with a polyacrylamide gel and a polyimide resin as the bonding agent.
Liang Zhao, Kaiping Feng, Tianchen Zhao, Zhaozhong Zhou, Junkai Ding   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Study on the Abrasive Blasting Mechanism of Solder Welded 304V Wire in Vascular Intervention

Micromachines
The solder burrs on the 304V wire surface can easily scratch the vascular tissue during interventional treatment, resulting in complications such as medial tears, bleeding, dissection, and rupture.
Yao Liu, Shaobo Zhai, Jinzhu Guo, Shiling Fu, Bin Shen, Zhigang Zhao, Qingwei Ding   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Investigation of impact load and erosion behaviors on Ti-Ta alloy surface through the synergistic effect of ultrasonic cavitation and micro-abrasive particles

Journal of Materials Research and Technology, 2023
Ti–Ta alloy micro-nano surface processing is crucial for achieving biocompatibility. To investigate the cavitation and micro-abrasive particle damage characteristics, and the deformation mechanism of Ti–Ta alloy material surface, indentation theory, and ...
Yingze Fu, Xijing Zhu, Jianqing Wang, Tai Gong, Shaohuan Sun, Jing Li, Linzheng Ye, Xiangmeng Li   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source