Results 101 to 110 of about 57,209 (299)

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Dlaczego Prorok zapomniał wersety Koranu? Kilka słów o koncepcji derogacji (nasẖ) w prawie muzułmańskim

Studia Religiologica
The concept of abrogation (nasẖ) in Islamic law refers to the annulment or replacement of a divine ruling by a later one, either in whole or partially.
Karolina Raczkiewicz
doaj   +1 more source

The theory of abrogation : a critical evaluation [PDF]

, 2006
Abrogation (naskh) in the Qur'an constitutes one of the most controversial issues in the Islamic legacy. There are two groups of scholars, one supporting it and the other denying its existence in the Qur'an.
Khan, Israr Ahmad
core  

Supplementary Video 7 from Determinants of Mitotic Catastrophe on Abrogation of the G₂ DNA Damage Checkpoint by UCN-01

, 2011
Supplementary Video 7 from Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN ...
Jeremy P.H. Chow (15064996), Randy Y.C. Poon (14877506), Kin Fan On (15064993), Yue Chen (73753), Hoi Tang Ma (25478)   +4 more
core   +1 more source

MZF1 Inhibits TGFβ‐1/SMAD Signaling by Transcriptionally Activating SnoN to Augment Tumorigenic Potential in Colon Cancer

Advanced Science, EarlyView.
This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng, Mengxi Huang, Yiting Wang, Hongyu Wang, Haimei Feng, Xiaoming Bai, Jie Chen, Ke Xu, Xiaoyuan Chu, Zengjie Lei   +9 more
wiley   +1 more source

Supplementary Video 10 from Determinants of Mitotic Catastrophe on Abrogation of the G₂ DNA Damage Checkpoint by UCN-01

, 2011
Supplementary Video 10 from Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN ...
Jeremy P.H. Chow (15064996), Randy Y.C. Poon (14877506), Kin Fan On (15064993), Yue Chen (73753), Hoi Tang Ma (25478)   +4 more
core   +1 more source

BRCA2 abrogation triggers innate immune responses potentiated by treatment with PARP inhibitors [PDF]

, 2019
International audienceHeterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary to non-cancerous cells, where BRCA2 deletion causes cell cycle arrest or cell death, tumors carrying BRCA2 inactivation continue to ...
Miar, Ana, Groelly, Florian,, Porru, Manuela, Di Vito, Serena, Wright, Benjamin, Biroccio, Annamaria, Lombardi, Emilia Puig, Groelly, Florian, J, Londoño-Vallejo, Arturo, Lockstone, Helen, E., Lockstone, Helen,, Reisländer, Timo, Harris, Adrian, Tarsounas, Madalena, Madalena Tarsounas, Annamaria Biroccio, Timo Reisländer, Helen Lockstone, Arturo Londoño-Vallejo, Adrian Harris, Ana Miar, Emilia Puig Lombardi, Florian J. Groelly, Manuela Porru, Serena Di Vito, Benjamin Wright   +25 more
core   +1 more source

Switching Spike Plasticity Shapes ACE2 Engagement Across SARS‐CoV‐2 Variants

Advanced Science, EarlyView.
Conformational plasticity governs SARS‐CoV‐2 spike function and ACE2 recognition. Using high‐speed AFM and single‐molecule force spectroscopy, we analyzed the ancestral spike and nine variants, revealing progressive rigidification from Delta, variable plasticity in Omicron sublineages, and JN.1 compaction.
Sarah Stainer, Rong Zhu, Manuel Reithofer, Gerhard Stadlmayr, Katharina Stadlbauer, Panchika Prangkio, Christoph Rippel, Markus Hahn, Aniko Eva Kasztner, Stefanie Stohl, Petr Bednar, Daniel Ruzek, David Glück, Robert Tampé, Gordana Wozniak‐Knopp, Yoo Jin Oh, Miriam Klausberger, Peter Hinterdorfer   +17 more
wiley   +1 more source

Supplementary Video 1 from Determinants of Mitotic Catastrophe on Abrogation of the G₂ DNA Damage Checkpoint by UCN-01

, 2011
Supplementary Video 1 from Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN ...
Jeremy P.H. Chow (15064996), Randy Y.C. Poon (14877506), Kin Fan On (15064993), Yue Chen (73753), Hoi Tang Ma (25478)   +4 more
core   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source