Results 71 to 80 of about 57,209 (299)

The Abrogation of Nazi Laws in the Early Period of Mg

, 2013
This chapter examines Nazi laws that must be abrogated in the early period of military government (MG). The report considers four major groups of laws that are in need of immediate abrogation: laws, and other legislative rules, which contradict the ...
Otto Kircheimer
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Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Arguments for abrogation in the Qur'an: A critique

, 2012
Many Muslim scholars such as Abu ‘Ubayd (d.224 A.H.), al-Nahhaas (d.377 A.H.), Makki (d.437 A.H.), Ibn al-‘Arabi (d543 A.H.), ibn al-Jawzi (d.597 A.H.), al-Zarkashi (d.794 A.H.), al-Suyuti (d.911 A.H.), al-Dehlawi (d.1176 A.H.), and al-Zurqani (d.1948 C ...
Khan, Israr Ahmad
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Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

طرق معرفة النسخ عند الأصوليين دراسة تأصيلية تطبيقية / Methods of Identifying Abrogation (Al-Naskh) According to Usul al-Fiqh Scholars: A Foundational and Applied Study [PDF]

مجلة الشريعة والقانون بالقاهرة
يتناول هذا البحث طرق معرفة النسخ عند الأصوليين دراسةً تأصيليةً تطبيقيةً، ويهدف إلى تحرير الطرق التي يُعرف بها الناسخ من المنسوخ، وتمييز المعتبر منها من المختلف فيه، وبيان أثرها في توجيه الخلاف الفقهي، وتتمثل مشكلة البحث في تفاوت اتجاهات الأصوليين في عرض ...
بلقاسم الزبيدي
doaj   +1 more source

Supplementary Video 5 from Determinants of Mitotic Catastrophe on Abrogation of the G₂ DNA Damage Checkpoint by UCN-01

, 2011
Supplementary Video 5 from Determinants of Mitotic Catastrophe on Abrogation of the G2 DNA Damage Checkpoint by UCN ...
Jeremy P.H. Chow (15064996), Randy Y.C. Poon (14877506), Kin Fan On (15064993), Yue Chen (73753), Hoi Tang Ma (25478)   +4 more
core   +1 more source

Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
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Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

Abrogation Magic: The Rules Enabling Act Process, Civil Rule 84, and the Forms [PDF]

, 2015
The Committee on the Federal Rules of Practice and Procedure seeks to abrogate Federal Rule of Civil Procedure 84 and its attendant Official Forms. Poof - after seventy-six years of service, the Committee will make Rule 84 and its forms disappear.
Coleman, Brooke
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