Results 41 to 50 of about 352,235 (294)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Sarf Öğretisinde Kural Dışı Kullanım Nedenleri/علل مخالفة القياس في الدرس الصرفي

Kocaeli İlahiyat Dergisi, 2020
تتناول هذه الدراسة قضية مخالفة القياس في مباحث علم الصرف من خلال فهم طبيعة العلل التي كانت وراء تلك المخالفات، إذ ظاهرة ترك القياس ظاهرة غامضة لكنها واسعة الحضور في مصنَّفات علم الصرف، إذ يكاد لا يخلو باب من الأبواب الصرفية من ألفاظ خالفت القوانين ...
Mahmoud Abs
doaj  

ABE Cubed: Advanced Benchmarking Extensions for ABE Squared

IACR Transactions on Cryptographic Hardware and Embedded Systems
Since attribute-based encryption (ABE) was proposed in 2005, it has established itself as a valuable tool in the enforcement of access control. For practice, it is important that ABE satisfies many desirable properties such as multi-authority and negations support.
Sven Argo, Marloes Venema, Doreen Riepel, Tim Güneysu, Diego F. Aranha   +4 more
openaire   +4 more sources

Seeds-Abs-GNRs complexes retain seeding ability and can be integrated into fibrillar networks.

, 2022
a) Aggregation kinetics assessed by ThT fluorescence of 10 μM Aβ40 in PBS (pH 7.4, 37°C) in absence (black) or presence of seeds at varying concentrations; 0.1 μM (orange), 0.5 μM (light blue), and 1 μM (yellow).
Jillian Madine (1869376), Mahmoud G. Soliman (3601703), Jack Sharkey (2836094), Raphaël Lévy (2650135), Hannah A. Davies (6851888)   +4 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Addition of Modifying Agents vs Basic Functional Properties of Moldings Made of ABS [PDF]

Archives of Metallurgy and Materials
Unconventional injection methods include i.e. blowing injection that allows for production of moldings with a lower weight while maintaining mechanical properties of detail.
M. Trzaskalska
doaj   +1 more source

Characterization of glass fibre reinforced polyamide/acrylonitrile butadiene-styrene composite for automotive application [PDF]

, 2009
Polyamide-6 (PA6), acrylonitrile-butadiene-styrene (ABS) and their blends are an important class of engineering thermoplastics that are widely used especially for automotive industries.
Rahmat, Abdul Razak, Arsad, Agus, Hassan, Azman, Wahit, Mat Uzir   +3 more
core  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source