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Pharmacology of absence epilepsy

open access: yesTrends in Pharmacological Sciences, 2003
Abstract Absence epilepsy, a disease predominantly of childhood, has long been known to arise from an aberration of the interplay between two brain regions, the cortex and the thalamus. Pharmacological treatment of the disorder has advanced little during past decades, with ethosuximide and sodium valproate remaining the principle drugs of choice ...
Jon-Paul A, Manning   +2 more
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Some of the next articles are maybe not open access.

Absence in childhood absence epilepsy

Neurology, 2013
Clinicians typically breathe a sigh of relief when they make the diagnosis of childhood absence epilepsy. The history is classic-a normal young child with myriad brief periods of staring. The clinic visit is powerful when the phenomena are replicated by having the child hyperventilate. Finally, the EEG is definitive.
Eileen P G, Vining, Liu Lin, Thio
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The Absence Epilepsies

Epilepsia, 1993
Four syndromes comprise the absence epilepsies. Each is classically associated with the absence seizure, although other syndromes also have absence attacks as part of their repertoire. The most common syndrome is childhood absence epilepsy; it usually occurs in the age range of 6–7 years.
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Childhood epilepsy and school absence

Tropical Doctor, 2008
Epilepsy is one of the most common diseases encountered among school children. Its effect on school attendance and academic performance is a major cause of concern to both parents and clinicians. In this communication, the absence rate and academic performance of 50 school children with epilepsy attending normal schools was compared with that of their
Roland C, Ibekwe, Ngozi C, Ojinnaka
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Mechanisms of generalized absence epilepsy

Brain and Development, 1998
Absence seizures represent bilaterally synchronous burst-firing of an ensemble of reciprocally connected neuronal populations located in the thalamus and neocortex. Recent studies demonstrate that neurons in the reticular thalamic nucleus (nRt), thalamic relay neurons (RNs), and neocortical pyramidal cells comprise a circuit that sustains the ...
Y, Futatsugi, J J, Riviello
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Epilepsy with myoclonic absences in siblings

Brain and Development, 2014
Epilepsy with myoclonic absences (EMAs) is a distinct form of childhood epilepsy characterized by a peculiar seizure type that identifies this condition.To describe the clinical, electroencephalographic features, treatment strategies and outcome in this first case series of two siblings with normal intelligence presenting with EMAs.Both siblings ...
Ajith, Cherian   +8 more
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Genetics of absence epilepsy in rats

Behavior Genetics, 1990
All rats of the WAG inbred strain show electrophysiological and behavioral phenomena reminiscent of human absence epilepsy. To study the genetic architecture of this kind of epilepsy, WAG rats were cross bred with inbred ACI rats which show no signs of epilepsy.
Peeters, B.W.M.M.   +4 more
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Lamotrigine in typical absence epilepsy

Brain and Development, 1999
Lamotrigine (LTG) is an anti-epileptic drug effective in partial seizures and generalized epilepsy. There is growing evidence of the usefulness of LTG in childhood (CAE) orjuvenile (JAE) absences resistant to previous treatment. In this study all patients were identified using strict diagnostic criteria and subdivided into two groups.
BUONI, SABRINA   +2 more
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Human absence epilepsies

1992
A historical review of the concept of absence seizures. Their clinical features are very suggestive but a diagnosis made solely on clinical grounds is not always safe. Comparable pitfalls exist in the interpretation of EEG patterns. Absence seizures belong to several epileptic syndromes. They are briefly described.
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The outcome of absence epilepsy

Neurology, 1996
We performed a meta-analysis of studies on absence epilepsy (AE) to ascertain whether the outcome of this well-defined type of epilepsy can be stated unequivocally. Using the Index Medicus and Medline CD+, we identified 1,619 publications. After applying the criteria of the International League against Epilepsy (ILAE) for AE, 26 publications on 23 ...
P A, Bouma   +4 more
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