Results 91 to 100 of about 2,549,711 (355)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Age of the Tokkalehto metagabbro and its significance to the lithostratigraphy of the early Proterozoic Kuusamo supracrustal belt, northern Finland [PDF]

open access: yesBulletin of the Geological Society of Finland, 2001
The c. 30-km2 Tokkalehto metagabbro and associated sills and dykes intrude a large part of the western part of the early Proterozoic Kuusamo supracrustal belt in northern Finland. These rocks have previously been mapped as a metavolcanic unit, Greenstone
P.M. Evins, K. Laajoki
doaj   +1 more source

Absolute Magnitudes of Seismic Red Clumps in the Kepler Field and SAGA: the age dependency of the distance scale

open access: yes, 2017
Red clump stars are fundamental distance indicators in astrophysics, although theoretical stellar models predict a dependence of absolute magnitudes with ages.
Aguirre, V. Silva   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The 3.5 Ga Siurua trondhjemite gneiss in the Archaean Pudasjärvi Granulite Belt, northern Finland [PDF]

open access: yesBulletin of the Geological Society of Finland, 2003
In the Archaean Pudasjärvi Complex the pyroxene-bearing rocks are considered to form a belt, the Pudasjärvi Granulite Belt (PGB). The major rock types of the PGB are meta-igneous mafic and felsic granulites, and trondhjemite gneisses Red alaskites, white
T. Mutanen, H. Huhma
doaj   +1 more source

Relative distances of Omega Centauri and 47 Tucanae

open access: yes, 2008
We present precise optical and near-infrared ground-based photometry of two Globular Clusters (GCs): Omega Cen and 47 Tuc. These photometric catalogs are unbiased in the Red Giant Branch (RGB) region close to the tip.
A. Calamida   +42 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

How well do we know the age and mass distributions of the star cluster system in the Large Magellanic Cloud?

open access: yes, 2005
[ABRIDGED] The LMC star cluster system offers the unique opportunity to independently check the accuracy of age and mass determinations based on a number of complementary techniques, including isochrone analysis.
Anders, Peter, de Grijs, Richard
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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