Results 181 to 190 of about 95,952 (294)

Synergistic Impacts of Co‐Exposure to Microplastics and Vibrio harveyi on the Immune and Stress Responses of the Big‐Belly Seahorse Hippocampus abdominalis

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Synergistic effects of microplastic and Vibrio harveyi co‐exposure on big‐belly seahorse (Hippocampus abdominalis). Seahorses were exposed to microplastics (50 beads/L of 0.2 μm SMP and 1.0 μm LMP) and injected with V. harveyi (1 × 103 CFU/mL).
Jin A Kim, Min‐Min Jung, Seong Don Hwang, Jun‐Hwan Kim, Cheol Young Choi   +4 more
wiley   +1 more source

Recycling of hazelnut waste: Antidiabetic properties of soy lecithin nanoparticles and their in vitro anti‐proliferative effects in tumor cell lines

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Hazelnuts and foods produced using hazelnuts are consumed with pleasure, but it is important to evaluate the waste generated during hazelnut processing and determine their usage methods. RESULTS This study was conducted to determine the changes in bioactive components, bioaccessibility and antidiabetic activity of nanoparticles ...
Mehmet Ali Temiz, Emine Okumus
wiley   +1 more source

A phase 1 study to assess the absolute bioavailability, mass balance, pharmacokinetics, metabolism, and excretion of [¹⁴C]-mobocertinib, an oral inhibitor of EGFR exon 20 insertion mutations, in healthy participants. [PDF]

Invest New Drugs
Hanley MJ, Zhang S, Griffin R, Zhu SX, Fram RJ, Lin J, Venkatakrishnan K, Gupta N.   +7 more
europepmc   +1 more source

Nutritional characterization of Cusco green tea and its synergistic effect with omega‐3 on metabolic and cognitive dysfunctions in obese rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity and its metabolic complications, such as insulin resistance and cognitive decline, remain a global health challenge. Green tea (Camelia sinensis) and ω‐3 polyunsaturated fatty acids (PUFAs) are recognized for their antioxidant, anti‐inflammatory, and neuroprotective properties.
Paola Finetti‐Casanova, Nataly Bernuy‐Osorio, Miguel Rodriguez‐Pozo, Aya Maaloul, Roberto T Abdala‐Diaz, Juan Decara   +5 more
wiley   +1 more source

Investigation of the absolute bioavailability and human mass balance of navoximod, a novel IDO1 inhibitor. [PDF]

Br J Clin Pharmacol, 2019
Ma S, Suchomel J, Yanez E, Yost E, Liang X, Zhu R, Le H, Siebers N, Joas L, Morley R, Royer-Joo S, Pirzkall A, Salphati L, Ware JA, Morrissey KM.   +14 more
europepmc   +1 more source

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Joint and Independent Associations of Dietary Antioxidant Intakes With Advanced Stages in Older Patients With Cardiovascular‐Kidney‐Metabolic Syndrome

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explored the association between the composite dietary antioxidant index (CDAI) and cardiovascular‐kidney‐metabolic (CKM) progression in an older population. Using data from NHANES 2001–2020, we analyzed 4974 adults aged ≥ 60 years with CKM syndrome. The CDAI was calculated from the intake of six dietary antioxidants.
Fu‐Shan Qiu, Jian‐Chao Qi, Mei‐Zhu Lin, Jun‐Hua Ke   +3 more
wiley   +1 more source

The Association Between Stress‐Induced Hyperglycemia Ratio and Increased Urinary Albumin Excretion in Patients With Hypertension: A Population‐Based Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The stress hyperglycemia ratio (SHR), a novel marker reflecting relative hyperglycemia, has been increasingly recognized for its prognostic value in cardiovascular and metabolic diseases. However, its association with early renal damage in hypertensive patients remains underexplored.
Kai‐Jun Zhang, Yun Lan, Wen‐Feng Zeng, Rong‐Ting Zhang, Zhi‐Yi Ma, Xin Zou   +5 more
wiley   +1 more source

Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact

The Laryngoscope, EarlyView.
ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase, Kjell Erik Julius Håkansson, Peter Schwarz, Kasper Aanæs, Jens Tidemandsen, Charlotte Suppli. Ulrik, Bente Appel Esbensen, Vibeke Backer   +7 more
wiley   +1 more source

Relative and Absolute Bioavailability Study of Emicizumab to Bridge Drug Products and Subcutaneous Injection Sites in Healthy Volunteers. [PDF]

Clin Pharmacol Drug Dev, 2019
Kotani N, Yoneyama K, Kawakami N, Shimuta T, Fukase H, Kawanishi T.   +5 more
europepmc   +1 more source