Results 81 to 90 of about 1,640,518 (270)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

On data-driven robust portfolio optimization with semi mean absolute deviation via support vector clustering [PDF]

Mathematics and Modeling in Finance
In [14] the authors have studied robust semi-mean absolute deviation portfolio optimization model when assets expected returns involve uncertainty. They applied a data driven approach via support vector clustering to construct the uncertainty set using ...
Eftekhar Kosarinia, Maziar Salahi, Tahereh Khodamoradi   +2 more
doaj   +1 more source

Robust Estimation of Reduced Rank Models to Large Spatial Datasets

Revstat Statistical Journal, 2020
For large datasets, spatial covariances are often modeled using basis functions and covariance of a reduced dimensional latent spatial process. For skewed data, likelihood based approaches with Gaussian assumption may not lead to faithful inference. Any
Casey M. Jelsema , Rajib Paul , Joseph W. McKean   +2 more
doaj   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Prediction-Based Portfolio Optimization Models Using Deep Neural Networks

IEEE Access, 2020
Portfolio optimization is a hot research topic, which has attracted many researchers in recent decades. Better portfolio optimization model can help investors earn more stable profits.
Yilin Ma, Ruizhu Han, Weizhong Wang
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

COMPARISON OF CONTROL CHART X ̅ BASED ON MEDIAN ABSOLUTE DEVIATION WITH S

Barekeng
A stable and controlled process will produce products of good quality following predetermined specifications. A control chart is one of the statistical tools that can be used to measure the stability of a product process in a controlled state.
Mayashari Mayashari, Erna Tri Herdiani, Anisa Anisa   +2 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Reconstructing the Local Twist of Coronal Magnetic Fields and the Three-Dimensional Shape of the Field Lines from Coronal Loops in EUV and X-Ray Images

, 2009
Non-linear force-free fields are the most general case of force-free fields, but the hardest to model as well. There are numerous methods of computing such fields by extrapolating vector magnetograms from the photosphere, but very few attempts have so ...
A. Malanushenko, Alissandrakis, Aschwanden, Burnette, D. E. McKenzie, D. W. Longcope, DeRosa, Lim, Press, Schrijver, van Ballegooijen   +10 more
core   +1 more source