Results 41 to 50 of about 1,872,325 (220)

Перспективы использования магнезиальных пород [PDF]

open access: yes, 2012
A new operation mode of the lens system in electron energy loss spectrometers is proposed which brings the cardinal plane of the lenses closer to the sample.
Ibach, H., Rajeswari, J.
core   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Deep Long Short-Term Memory Adaptive Beamforming Networks For Multichannel Robust Speech Recognition

open access: yes, 2017
Far-field speech recognition in noisy and reverberant conditions remains a challenging problem despite recent deep learning breakthroughs. This problem is commonly addressed by acquiring a speech signal from multiple microphones and performing ...
Erdogan, Hakan   +3 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Integrated characteristics triangulable 3D models of products [PDF]

open access: yes, 2011
Рассмотрены интегральные характеристики триангуляционных 3D моделей промышленных изделий. Абсолютные интегральные характеристики представлены следующими группами: линейные, угловые, поверхностные и объемные.
Абдурайимов, Л. Н.   +2 more
core  

An evaluation framework for stereo-based driver assistance [PDF]

open access: yes, 2012
This is the post-print version of the Article - Copyright @ 2012 Springer VerlagThe accuracy of stereo algorithms or optical flow methods is commonly assessed by comparing the results against the Middlebury database.
Banitsas, KA   +3 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola   +12 more
wiley   +1 more source

IMPACT OF AMT INVESTMENTS ON EFFECTIVENESS AND COMPETITIVENESS OF MANUFACTURING SYSTEMS [PDF]

open access: yes
Every manufacturing company is a system of individual manufacturing units, which have to be carefully laid out taking into account time, space, technology, and organisation perspective in order to deliver maximum final product.
Miroslav Chodur, Premysl Palka
core  

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