Results 141 to 150 of about 69,015 (252)

Napabucasin transforms liver microenvironment and boosts immunotherapy efficacy by converting potential metastases into “hot” tumors

Interdisciplinary Medicine, EarlyView.
Napabucasin reduces liver metastases by reprogramming the hepatic microenvironment. It induces hepatocyte secretion of CCL21 via c‐Fos activation, recruiting lymphocytes and converting “cold” metastases into immunologically “hot” tumors. This effect is liver‐specific and independent of cancer cells.
Qiongqiong Wang, Jiaqi Zhou, Hang Qiao, Yifan Jia, Ling Ye, Zeli Li, Jiahe Ouyang, Haoxian Zhou, Kangxin Zeng, Xuemeng Wang, Yixian Wang, Yang Zhang, Yupeng Zhang, Yizhou Cai, Yutao Hu, Minzhe Zhang, Wenwei Xu, Zhenzhen Wu, Xiaofang Qiu, Li Lin   +19 more
wiley   +1 more source

Low Absolute Lymphocyte Count Associated With Anti-Thymocyte Globulin Induction May Be a Predictor of Early Cytomegalovirus Infection in Pediatric Heart Transplantation. [PDF]

Pediatr Transplant
Chan A, Tan R, Tan S, Kuhn M, Shwaish N, Chinnock R, Tran H, Frandsen E.   +7 more
europepmc   +1 more source

Prognostic value of absolute lymphocyte count in patients with advanced esophageal cancer treated with immunotherapy: a retrospective analysis. [PDF]

Ann Transl Med, 2022
Zhao Q, Bi Y, Xue J, Liu Y, Zhu J, Qin S.   +5 more
europepmc   +1 more source

Lymph‐based liquid biopsy: Current progress and future potential

Interdisciplinary Medicine, EarlyView.
Recent evidence under the revised Starling principle indicates that lymph‐based liquid biopsies may offer superior diagnostic performance over blood‐based counterparts in certain clinical scenarios, such as early‐stage solid tumor detection. Currently, various biomarkers within the lymphatic system show significant diagnostic potential for a range of ...
Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo   +6 more
wiley   +1 more source

Flow Cytometric Profiling Reveals Platelet Dysfunction and Impaired Immune Communication in Acute and Chronic Cerebrovascular Disease

Journal of Clinical Laboratory Analysis, EarlyView.
Platelets act as sensors linking inflammation and neurovascular health. Flow cytometry revealed reduced PAC‐1 in acute/subacute ICH but elevated in chronic disease, while P‐selectin remained suppressed. T lymphocyte–platelet aggregates declined across groups, indicating disrupted immune crosstalk, and these biomarkers reflect stage‐specific platelet ...
Chih‐Lung Shen, Li‐Yu Huang, Jhong‐Kuei Chen, Sheng‐Tzung Tsai, Yi‐feng Wu   +4 more
wiley   +1 more source

Blood absolute lymphocyte count and trajectory are important in understanding severe COVID-19. [PDF]

BMC Infect Dis
Paules CI, Nordwall JA, Shaw-Saliba K, Aberg JA, Gardner EM, Goodman AL, Kumarasamy N, Vasudeva S, Vock DM, North CM, Lundgren J, Aggarwal NR, STRIVE Network and TICO Trial Study Group.   +12 more
europepmc   +1 more source

Preoperative Absolute Lymphocyte Count to Carcinoembryonic Antigen Ratio Is a Superior Predictor of Survival in Stage I to III Colorectal Cancer. [PDF]

Clin Med Insights Oncol, 2022
Zhou Y, Cheng F, Zhang Z, Xiang J, Xue T, Ye Q, Yan B.   +6 more
europepmc   +1 more source

Novel Laboratory Approaches in Heavy Chain Disease With Discordant Immunoglobulin Quantitation: A Case Report and Literature Review

Journal of Clinical Laboratory Analysis, EarlyView.
In this study, we investigated a rare case of γ‐heavy chain disease (γ‐HCD) through an integrated laboratory approach. Routine protein analyses (serum protein electrophoresis, immunotyping, and serum/urine immunofixation) identified an IgG monoclonal component without detectable light chains.
Eleonora Longhi, Artan Çeka, Fabiola Olivieri, Marco Moretti, Jacopo Sabbatinelli   +4 more
wiley   +1 more source

Prognostic value of neutrophil-lymphocyte ratio, absolute lymphocyte count, and thrombocyte-lymphocyte ratio in predicting the outcomes of tetralogy of fallot primary repair. [PDF]

Front Cardiovasc Med
Siagian SN, Christianto C.
europepmc   +1 more source

Intravenous injection of a novel viral immunotherapy encoding human interleukin-7 in nonhuman primates is safe and increases absolute lymphocyte count. [PDF]

Hum Vaccin Immunother, 2022
Coupet CA, Dubois C, Evlachev A, Kehrer N, Baldazza M, Hofman S, Vierboom M, Martin P, Inchauspe G.   +8 more
europepmc   +1 more source