Results 61 to 70 of about 436,125 (330)

Density modulation-induced absolute laser-plasma-instabilities: simulations and theory [PDF]

, 2016
Fluid simulations show that when a sinusoidal density modulation is superimposed on a linear density profile, convective instabilities can become absolutely unstable. This conversion can occur for two-plasmon-decay and stimulated Raman Scattering instabilities under realistic direct-drive inertial confinement fusion conditions and can affect hot ...
arxiv   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

TASTE SENSITIVITY CHANGES AMONG CONSUMERS OF PEMPEK-CUKO IN PALEMBANG CITY, SOUTH SUMATRA, INDONESIA [PDF]

Russian Journal of Agricultural and Socio-Economic Sciences
Pempek is a typical food from Palembang, Indonesia. It is commonly consumed with cuko, a dipping sauce containing acetic acid which is corrosive. The research aimed to determine the absolute and recognition threshold, as well as changes in tongue ...
Budianto, Pratama F., Syafutri M.I.
doaj  

Lower Bound on Weights of Large Degree Threshold Functions [PDF]

Logical Methods in Computer Science, 2013
An integer polynomial $p$ of $n$ variables is called a \emph{threshold gate} for a Boolean function $f$ of $n$ variables if for all $x \in \zoon$ $f(x)=1$ if and only if $p(x)\geq 0$.
Vladimir V. Podolskii
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

Absolute quantification of real-time PCR data with stage signal difference analysis [PDF]

arXiv, 2021
Real-time PCR, or Real-time Quantitative PCR (qPCR) is an effective approach to quantify nucleic acid samples. Given the complicated reaction system along with thermal cycles, there has been long-term confusion on accurately calculating the initial nucleic acid amounts from the fluorescence signals.
arxiv  

Behavioral estimates of absolute visual threshold in mice

Vision Research, 1997
Behavioral measurements on the water maze show night blindness in albino mice but cortical recordings show no difference between pigmented and congenic albino mice. Consequently we have measured the absolute threshold in albino and pigmented mice using an operant method. The estimated threshold value is -5.3 log cd/m2 for albino mice and -5.5 log cd/m2
Carmen Costi, Pilar Herreros de Tejada, Carmen Muñoz Tedó   +2 more
openaire   +3 more sources