Results 71 to 80 of about 121,812 (260)
Radiation Protection and EnvironmentAstronauts on space missions are exposed to high radiation levels, especially from galactic cosmic rays (GCRs), which consist of particles with high energy such as protons, helium ions, and heavy ions.
Rohit Yadav +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Nuclear AnalysisA total of 17 soil samples were randomly collected from agricultural farms around mining areas from Karibib, Erongo region, Namibia. The samples were analyzed for natural radioactivity using a high purity germanium (HPGe) detector.
Sylvanus Ameh Onjefu +7 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Iraqi Journal of Physics, 2019 The aim of this work was directed to measure the cosmic ray (CR) flux and the background (BG) absorbed dose rate for districts of Baghdad city. The maximum values of CR flux was 2.01 (particle/cm2.s) registered for several Baghdad districts and the ...
Shafik S. Shafik
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Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Long‐Term Variation of the Galactic Cosmic Ray Radiation Dose Rates
Space WeatherIn this work, a model for calculating the galactic cosmic rays (GCRs) radiation dose rate is developed. The model is based on a GCR modulation model, which is established by Shen and Qin, and the fluence‐dose conversion coefficients (FDCCs) published by ...
D. Lyu, G. Qin, Z.‐N. Shen
doaj +1 more source