Results 71 to 80 of about 1,774,464 (332)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Study on Reliability of Water Absorption Diagnosis through Precise Water Absorption Test

open access: yesJournal of Electrical Engineering and Technology, 2012
Accidents caused by water absorption in water-cooled generator stator windings often occur all over the world. The absorption into the insulator of the coolant, which is used to cool down the heat generated by stator windings during operation, leads to the deterioration of dielectric strength, and insulation breakdown. An insulation breakdown may cause
Hee-Soo Kim, Yong-Chae Bae, Hee-Dong Kim
openaire   +2 more sources

Improving the quality of various types of recycled aggregates by biodesposition [PDF]

open access: yes, 2017
Demand for construction materials has been rising in recent decades in many countries around the world, placing a heavy burden on the environment in terms of both the natural resources consumed and the enormous flow of waste generated. In order to obtain
Boon, Nico   +7 more
core   +1 more source

Towards Spectral Classification of L and T Dwarfs: Infrared and Optical Spectroscopy and Analysis [PDF]

open access: yes, 2001
We present 0.6-2.5um, R~400 spectra of twenty-seven cool, low luminosity stars and substellar objects. Based on these and previously published spectra we develop a preliminary spectral classification system for L and T dwarfs.
Anderson, S   +28 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Using the right slope of the 970 nm absorption feature for estimating canopy water content [PDF]

open access: yes, 2009
Canopy water content (CWC) is important for understanding the functioning of terrestrial ecosystems. Biogeochemical processes like photosynthesis, transpiration and net primary production are related to foliar water.
Clevers, J.G.P.W.   +2 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Correlation of Water Absorption Values of Bitumen Waterproofing Sheets Obtained According to CSN EN 14223 and CSN 503602

open access: yesCommunications, 2014
The article deals with the issue of weight water absorption of bitumen waterproofing sheets. It compares two methodologies applicable to examination of water absorption of bitumen waterproofing sheets from the point of view of testing procedures.
Jan Plachy   +3 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

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