Results 91 to 100 of about 158,242 (253)
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Types of metaphors and mechanisms of comprehension
Cogent Education, 2019 Describing the processes of metaphor comprehension has been a hot topic of discussion among researchers throughout the past four decades. One of the major challenges has been to find a mechanism that can describe the processes involved in the ...
Hassan Banaruee +3 more
doaj +1 more source
Different domains in abstract concepts
, 2005 This study is a first attempt to unravel the almost unexplored domain of abstract conceptual knowledge. Four kinds of abstract concepts (nominal kinds, states of the self, cognitive processes, and emotion concepts) were investigated in two experiments.
Caramelli, Nicoletta, Setti, Annalisa
openaire +3 more sources
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Social semantics: the organization and grounding of abstract concepts. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2023 Pexman PM, Diveica V, Binney RJ.
europepmc +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
The Role of the Visual Versus Verbal Modality in Learning Novel Verbs
ChildrenBackground/Objectives: Verbs are considered to be more abstract than nouns, as they represent actions, states, and events, which are less tangible, more flexible in their meaning and thus less univocally specified.
Maria Luisa Lorusso +6 more
doaj +1 more source
Concrete and Abstract Concepts in Primary Progressive Aphasia and Alzheimer's Disease: A Scoping Review. [PDF]
Brain Sci, 2023 Mancano M, Papagno C.
europepmc +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
A context-sensitive and non-linguistic approach to abstract concepts. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2023 Langland-Hassan P, Davis CP.
europepmc +1 more source