Results 131 to 140 of about 8,638,029 (373)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

A user profiling component with the aid of user ontologies [PDF]

, 2003
: What follows is a contribution to the field of user modeling for adaptive teaching and learning programs especially in the medical field. The paper outlines existing approaches to the problem of extracting user information in a form that can be ...
István-Tibor, Nébel, Ralf, Paschke, Smith, Barry   +2 more
core   +2 more sources

Most autophagic cell death studies lack evidence of causality

FEBS Open Bio, EarlyView.
Of 104 studies claiming autophagic cell death (ACD), only 13 demonstrated both causality and exclusion of apoptosis to confirm true ACD. Most studies relied on correlation‐level data or measured autophagy in isolation, revealing pervasive methodological shortcomings.
Ali Burak Özkaya, Yasmin Ghaseminejad
wiley   +1 more source

Learning the fine-grained code representation for log-level prediction

Journal of King Saud University: Computer and Information Sciences
Log levels are crucial to distinguish the severity of logs and directly reflecting the urgency of transactions in software systems. Automatically and efficiently determining log levels is a crucial and challenging task in log management.
Zhiyong Zhao, Guodong Fan, Jing Li, Ming Zhu, Haotian Zhang, Hongli Su   +5 more
doaj   +1 more source

Abstract data type support in Prolog and its relation to parallelism [PDF]

, 1994
Isambo Karali, C. Halatsis
openalex   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

近25 a 银川市城市化进程中热力景观格局演变分析 [PDF]

, 2016
： Based on the Landsat images and statistical data，in this paper the urbanization process and thermal landscape dynamics of Yinchuan City were analyzed． The objectives of this study were as follows: ① To analyze the spatial and dynamic characteristics of
吕荣芳, 张建明, 王浩, 王鹏龙
core  

Network pharmacology‐based screening and pharmacokinetic evaluation of key active compounds in Jinhong tablets against chronic superficial gastritis

Advanced Chinese Medicine, EarlyView.
Schematic representation of the study design and methodology. Abstract Ethnopharmacological relevance Jinhong tablet (JHT), a traditional Chinese patent medicine prepared from four Chinese medicinal materials, is highly effective in soothing the liver and relieving depression, regulating qi and promoting blood circulation, and regulating the stomach ...
Tingyu Zhang, Jian Feng, Mengyu Qian, Xia Gao, Xialin Chen, Ran Xiao, Hongyu Peng, Xiaoxue Fan, Xin Meng, Mingke Yin, Zhenzhong Wang, Bo Zhang, Liang Cao   +12 more
wiley   +1 more source

Identification and functional characterization of EFNA3 as a dual diagnostic biomarker and immune therapeutic target in rectal cancer

Advanced Chinese Medicine, EarlyView.
Abstract Background The Eph/ephrin signaling system has emerged as an important regulator of oncogenic processes, yet its specific involvement in rectal adenocarcinoma (READ) pathogenesis requires further elucidation. This study employed an integrative analytical approach combining computational biology with experimental validation to characterize Eph ...
Tianqi Liu, Jiuyuan Fang, Bohan Liu, Hangqi Liu, Yidan Wang, Yipei Jing, Hui Zhang, Huanwen Wu   +7 more
wiley   +1 more source

Missing cell types in single-cell references impact deconvolution of bulk data but are detectable

Genome Biology
Background Advancements in RNA sequencing have expanded our ability to study gene expression profiles of biological samples in bulk tissue and single cells.
Adriana Ivich, Natalie R. Davidson, Laurie Grieshober, Weishan Li, Stephanie C. Hicks, Jennifer A. Doherty, Casey S. Greene   +6 more
doaj   +1 more source