Results 71 to 80 of about 725,779 (280)
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
On the spectrum of weakly almost periodic solutions of certain abstract differential equations
International Journal of Mathematics and Mathematical Sciences, 1985 In a sequentially weakly complete Banach space, if the dual operator of a linear operator A satisfies certain conditions, then the spectrum of any weakly almost periodic solution of the differential equation u′=Au+f is identical with the spectrum of f ...
Aribindi Satyanarayan Rao, L. S. Dube
doaj +1 more source
Abstract Schroedinger-Type Differential Equations with Variable Domain
Journal of Mathematical Analysis and Applications, 1997 Existence and uniqueness results for suitably defined weak solutions to the Cauchy problem for a class of linear abstract differential equations of Schrödinger type with variable domain are proved.
BERNARDI M. L +2 more
openaire +3 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Massera Type Theorems for Abstract Functional Differential Equations
Funkcialaj Ekvacioj, 2008 18 ...
Liu, Qing +3 more
openaire +4 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Journal of Inequalities and Applications, 2005 We establish optimal, in a sense, unique solvability conditions of the Cauchy problem for a wide class of linear functional differential equations in a Banach space with a solid wedge.
Šremr Jiří +1 more
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Solvability and completeness of solutions of parabolic differential-operator equations [PDF]
Математичні Студії, 2011 We consider an abstract Cauchy problem for parabolic differential-operator equations in Hilbert spaces. Initial boundary value problems for parabolic equations are reduced to the Cauchy problem for a system of parabolic differential equations.
M. M. Mamedov
doaj
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source