Results 101 to 110 of about 590,012 (309)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Incremental analysis of constraint logic programs
, 2000 Global analyzers traditionally read and analyze the entire program at once, in a nonincremental way. However, there are many situations which are not well suited to this simple model and which instead require reanalysis of certain parts of a program ...
Stuckey, P.J. +7 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Correctness kernels of abstract interpretations
Information and Computation, 2014 In abstract interpretation-based static analysis, approximation is encoded by abstract domains. They provide systematic guidelines for designing abstract semantic functions that approximate some concrete system behaviors under analysis. It may happen that an abstract domain contains redundant information for the specific purpose of approximating a ...
Roberto Giacobazzi, RANZATO, FRANCESCO
openaire +4 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Comparing Tag Scheme Variations Using an Abstract Machine Generator
, 2008 In this paper we study, in the context of a WAM-based abstract machine for Prolog, how variations in the encoding of type information in tagged words and in their associated basic operations impact performance and memory usage.
Morales Caballero, José Francisco +5 more
core +1 more source
PARAPHRASICAL INTERTEXTUALITY: INTERPRETATION MARKS IN THE SCIENTIFIC ABSTRACT GENRE
Travessias, 2010 This article aims to analyze a production of the scientific abstract genre, written by a student of 1st year of Arts, at Universidade Estadual de Maring, with the purpose of investigate the existence of marks of paraphrasical intertextuality which leads ...
Rubia Mara Bragagnollo
doaj
A Quantum Formalism for Abstract Dynamical Systems
MathematicsThis paper presents a quantum formulation for classical abstract dynamical systems (ADS), defined by coupled sets of first-order differential equations. They are referred to as “abstract” because their dynamical variables can be of different interrelated
Joan C. Micó
doaj +1 more source
On abstract interpretation of Mobile Ambients
Information and Computation, 2004 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
LEVI, FRANCESCA, MAFFEIS S.
openaire +3 more sources
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source