Results 131 to 140 of about 6,513,935 (304)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Book review: COLIVA, Annalisa. The Varieties of Self-Knowledge . London: Palgrave Macmillan, 2016. 288p.

open access: yesManuscrito
In this review, I argue that Coliva's strong transparency admits three possible interpretations: (a) a Wittgensteinian interpretation, (b) a metaphysical interpretation, and (c) an epistemic interpretation. I favor (c) over (a) and (b).
Alexandre de Borba
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

DWORKIN: DE QUE MANEIRA O DIREITO SE ASSEMELHA À LITERATURA?

open access: yesRevista da Faculdade de Direito da Universidade Federal de Minas Gerais, 2013
Este artigo visa a reconstruir a argumentação desenvolvida por Ronald Dworkin, em A Matter of Principle, acerca de como a interpretação jurídica se assemelha à interpretação literária.
Marcelo Cattoni Andrade de Oliveira
doaj   +4 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Verification, Model Checking, and Abstract Interpretation

open access: yes, 2014
International audienceThis book constitutes the refereed proceedings of the 15th International Conference on Verification, Model Checking and Abstract Interpretation, VMCAI 2014, held in San Diego, CA, USA, in January 2013.
Rival, Xavier, Mcmillan, Kenneth
core   +3 more sources

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

Abstract Local Completeness

open access: yes
The Abstract interpretation offers sound and decidable approximations for undecidable queries related to program behavior. The effectiveness of an abstract interpretation process relies entirely on the abstract domain itself, and the worst-case scenario ...
Mastroeni, Isabella
core   +1 more source

The Interpretation of Non-Sentential Utterances in Dialogue [PDF]

open access: yes, 2003
Schlangen D, Lascarides A. The Interpretation of Non-Sentential Utterances in Dialogue. In: Rudnicky A, ed. Proceedings of the 4th SIGdial workshop on Discourse and Dialogue.
Schlangen, David ; https://orcid.org/   +2 more
core  

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