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Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Developing a Detailed Chemical Kinetic Model for Combustion of <i>Iso</i>-Cetane Based on Ignition and Oxidation. [PDF]

Molecules
Chen P, Heng Y, Zhao B, Zhu N, Liang J, Li G.   +5 more
europepmc   +1 more source

Graph Topology Reframes the Coherence of Cell-State Manifold Inference under Heterogeneous Single-Cell Observations. [PDF]

Comput Struct Biotechnol J
Tamura T, Yamane Y, Okano Y, Ishikawa T, Sakurada K.   +4 more
europepmc   +1 more source

Data-Driven Approach to Understanding Tetrabutylammonium Decatungstate-Catalyzed C(sp³)-H Functionalization Selectivity. [PDF]

Angew Chem Int Ed Engl
Lavin M, Tekle-Smith MA.
europepmc   +1 more source

Orchestrating agentic systems at ALS beamline 5.3.1 with Osprey and Bluesky. [PDF]

J Synchrotron Radiat
Chan KH, Ha Y, Islegen-Wojdyla A, Leon S, Garces M, McReynolds D, Chong X, Sriramoju RV, Mahl J, Guenzing D, Koepp W, Hexemer A, Hellert T, Chavez T.   +13 more
europepmc   +1 more source

Public availability of trial-design and clinical-context information in contemporary lipoprotein(a)-targeted cardiovascular trials: A cross-sectional meta-research study. [PDF]

Am Heart J Plus
Tan S, Gu J, Yow D, Zheng L.
europepmc   +1 more source

Influence of Primary Coordination Sphere on Anion Rebound Selectivity in Nonheme Fe Enzyme-Catalyzed C(sp3)-H Functionalization: A Comparative Experimental and Computational Study of EgtB and ACCO. [PDF]

J Am Chem Soc
Zhao LP, Guo R, Mai BK, Chen H, Liu P, Yang Y.   +5 more
europepmc   +1 more source

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Abstraction and interpretation during the qualitative content analysis process

International Journal of Nursing Studies, 2020
Britt Marie Lindgren, Berit Lundman, Ulla H Graneheim   +2 more
exaly