Results 41 to 50 of about 914,128 (308)
Wonderland: A Novel Abstraction-Based Out-Of-Core Graph Processing System
International Conference on Architectural Support for Programming Languages and Operating Systems, 2018 Many important graph applications are iterative algorithms that repeatedly process the input graph until convergence. For such algorithms, graph abstraction is an important technique: although much smaller than the original graph, it can bootstrap an ...
Mingxing Zhang +5 more
semanticscholar +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Network protocol scalability via a topological Kadanoff transformation
, 2008 A natural hierarchical framework for network topology abstraction is presented based on an analogy with the Kadanoff transformation and renormalisation group in theoretical physics.
Constantinou, C. C., Stepanenko, A. S.
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Abstraction and its Limits: Finding Space for Novel Explanation. [PDF]
, 2012 Several modern accounts of explanation acknowledge the importance of abstraction and idealization for our explanatory practice. However, once we allow a role for abstraction, questions remain. I ask whether the relation between explanations at different
Knox, Eleanor
core
Pondering the Concept of Abstraction in (Illustrative) Visualization
IEEE Transactions on Visualization and Computer Graphics, 2018 We explore the concept of abstraction as it is used in visualization, with the ultimate goal of understanding and formally defining it. Researchers so far have used the concept of abstraction largely by intuition without a precise meaning.
I. Viola, Tobias Isenberg
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Imperfect-Recall Abstractions with Bounds in Games
, 2016 Imperfect-recall abstraction has emerged as the leading paradigm for practical large-scale equilibrium computation in incomplete-information games. However, imperfect-recall abstractions are poorly understood, and only weak algorithm-specific guarantees ...
Kroer, Christian, Sandholm, Tuomas
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Graph Abstraction and Abstract Graph Transformation [PDF]
, 2007 Many important systems like concurrent heap-manipulating programs, communication networks, or distributed algorithms are hard to verify due to their inherent dynamics and unboundedness.
Bauer, J. +3 more
core +1 more source