Results 201 to 210 of about 1,016,650 (228)
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Aging and Cancer, EarlyView.This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel +4 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela +13 more
wiley +1 more source
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Journal of the American Geriatrics Society, 1983
Osteomyelitis beneath pressure sores . Sugarman B, Hawes S, Musher DM, et al. Arch Intern Med 143: 683, 1983 (21 references) Sometimes pressure sores fail to heal despite aggressive treatment.
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Osteomyelitis beneath pressure sores . Sugarman B, Hawes S, Musher DM, et al. Arch Intern Med 143: 683, 1983 (21 references) Sometimes pressure sores fail to heal despite aggressive treatment.
+6 more sources
Proceedings of the 2nd international workshop on The role of abstraction in software engineering, 2008
An abstraction is the reification and conceptualization of a distinction. We use the process of forming abstractions to make sense of the world, i.e., to form concepts. Once created we are often able to externalize these concepts as software. Abstractions are what give software elegance.
Russ Abbott, Chengyu Sun
openaire +1 more source
An abstraction is the reification and conceptualization of a distinction. We use the process of forming abstractions to make sense of the world, i.e., to form concepts. Once created we are often able to externalize these concepts as software. Abstractions are what give software elegance.
Russ Abbott, Chengyu Sun
openaire +1 more source