Results 71 to 80 of about 116,839 (261)

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

open access: yesAdvanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li   +9 more
wiley   +1 more source

A Peripheral Mechanism of Depression: Disturbed Intestinal Epithelial Per2 Gene Expression Causes Depressive Behaviors in Mice with Circadian Rhythm Disruption via Gut Barrier Damage and Microbiota Dysbiosis

open access: yesAdvanced Science, EarlyView.
Circardian rhythm disorder (CRD) causes abnormal expression of intestinal Period 2 (Per2) gene, which compromising intestinal barrier integrity and altering the gut microenvironment. Microbiota dysbiosis and aberrant metabolites production drive central inflammation, impair neurogenesis, and promote functional deficits, ultimately facilitating the ...
Huiliang Zhang   +16 more
wiley   +1 more source

Automating the analysis of fish abundance using object detection: optimising animal ecology with deep learning [PDF]

open access: green, 2019
Ellen M. Ditria   +5 more
openalex   +1 more source

Lords of the flies: dipteran migrants are diverse, abundant and ecologically important

open access: yesBiological Reviews
ABSTRACTInsect migrants are hugely abundant, with recent studies identifying the megadiverse order Diptera as the major component of many migratory assemblages. Despite this, their migratory behaviour has been widely overlooked in favour of more ‘charismatic’ migrant insects such as butterflies, dragonflies, and moths.
Will L. Hawkes   +2 more
openaire   +2 more sources

Inhibition of RNase to Attenuate Fungal‐Manipulated Rhizosphere Microbiome and Diseases

open access: yesAdvanced Science, EarlyView.
Fusarium graminearum uses its virulence effector Fg12, a fungal RNase, to manipulate the host rhizosphere microbiome and promote infection. Guanosine monophosphate (GMP) blocks Fg12's RNase activity. This reveals a key pathogen‐microbiota interaction mechanism and proposes GMP as a targeted strategy to disarm this core fungal effector, offering a ...
Bo Yang   +13 more
wiley   +1 more source

Abundance and distributional ecology of cetaceans in the central Philippines

open access: diamond, 2023
M. Louella L. Dolar   +4 more
openalex   +2 more sources

In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase‐Like Catalytic Activity for Oral Disease Detection

open access: yesAdvanced Science, EarlyView.
A novel copper silicate nanozyme (CSHSs‐Ar) with high peroxidase‐like catalytic activity and great catalytic specificity is well developed using a facile in situ valence‐engineered approach. The well‐developed CSHSs‐Ar nanozyme‐involved system can be utilized and employed as an efficient colorimetric sensor for the detection of volatile sulfur ...
Xiaocan Liu   +9 more
wiley   +1 more source

Carbonyls Mediated Dual‐Function Enables High‐Performance Carbon Anodes in Ester‐based Electrolyte

open access: yesAdvanced Science, EarlyView.
Based on a surface reconstruction strategy, hollow mesoporous carbon spheres with numerous C═O moieties are developed. Systematic characterizations demonstrate that the presence of C═O presents a double‐functional behavior. On the one hand, C═O has a stronger affinity to K‐salt than solvent molecules, thus catalyzing the preferential decomposition of K‐
Ziyu Wu   +8 more
wiley   +1 more source

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