Results 121 to 130 of about 2,332,140 (313)

Abuse upon abuse?

, 2017
Allowing alleged abusers to cross examine their victims is a stain on the reputation of the family justice system. Jonathan Herring puts the case for reform.
openaire   +1 more source

Dextromethorphan abuse [PDF]

Canadian Medical Association Journal, 2014
Tony, Antoniou, David N, Juurlink
openaire   +2 more sources

Sexual Harassment in the Workplace: A report from Field Research in Thailand [PDF]

, 2002
This study explores sexual harassment, including violent abuse and discrimination, in export industries in Thailand. The research is comprised of a survey of 100 factory workers from ten export industries.
Kompipote, Ubon
core   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

[11C]Fentanyl: radiosynthesis and preclinical pet imaging for its pharmacokinetics

EJNMMI Radiopharmacy and Chemistry
Background Fentanyl is a potent synthetic opioid widely used for pain management and anesthesia, but the high prevalence of its misuse and its key contribution to overdose fatalities in the United States have made it a major drug of concern.
Woochan Kim, Aaron K. Wozniak, Nathaniel J. Burkard, Michael L. Freaney, Ailen Costamagna-Soto, Kelly A. O’Conor, Abolghasem Bakhoda, Seth M. Eisenberg, Wenjing Zhao, Jeih-San Liow, Nora D. Volkow, Sung Won Kim   +11 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Guidelines for Organizing Art Exhibitions on Addiction and Recovery [PDF]

, 2009
Outlines the Innovators Combating Substance Abuse program's model for exhibiting art by those in addiction recovery as a way to offer insight into substance abuse and recovery.

core  

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Investigation of [11C]carfentanil for mu opioid receptor quantification in the rat brain

Scientific Reports
[11C]Carfentanil ([11C]CFN) is the only selective carbon-11 labeled radiotracer currently available for positron emission tomography (PET) imaging of mu opioid receptors (MORs).
Andrew C. Kelleher, Torben D. Pearson, Joseph Ramsey, Wenjing Zhao, Kelly A. O’Conor, Abolghasem Bakhoda, Tyler Stodden, Min Guo, Seth M. Eisenberg, Sarthak V. Shah, Michael L. Freaney, Woochan Kim, Yeona Kang, Dardo Tomasi, Christopher Johnson, Chung-An Fang, Nora D. Volkow, Sung Won Kim   +17 more
doaj   +1 more source