Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia +3 more
wiley +1 more source
Student-athletes at risk: faculty voices on gender-based violence and the need for structural change in physical activity and sport sciences programs. [PDF]
Serra Payeras P +3 more
europepmc +1 more source
Abstract Aims Cannabidiol (CBD), the main non‐intoxicating compound from the cannabis plant, is regularly used by patients with chronic pain who also take analgesics. CBD has previously been shown to inhibit CYP‐mediated drug metabolism. This study aimed to characterize the potential pharmacokinetic interaction of CBD with amitriptyline and tramadol ...
Andriy A. Gorbenko +9 more
wiley +1 more source
Denial of access to sexual and reproductive health services in Europe: an analysis of cases from the European court of human rights (1976-2023). [PDF]
Groff E, Steger F.
europepmc +1 more source
Zuranolone: A case study in (regulatory) rush to judgement?
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
wiley +1 more source
A responsive governance path to health equity: the role of state-led public interest litigation in China. [PDF]
Qi F, Yu B.
europepmc +1 more source
CHARACTERISTICS OF SUBJECTS OF ABUSE OF PROCEDURAL RIGHTS IN ADMINISTRATIVE PROCEEDINGS
openaire +1 more source
Psychological features of dispute content and public acceptance of AI in legal adjudication: evidence for systematic variation beyond individual differences. [PDF]
Fujita M, Watamura E.
europepmc +1 more source
‘Where are the adults?’: Troubling child‐activism and children's political participation
Abstract Children's political participation is a well‐established theme in childhood studies. In this article we offer an original account of child activism that takes into account the entangled and emergent aspect of children as activists. We begin with a historical and a conceptual review, noting the importance of mid‐20th century developments such ...
Sharon Hunter, Claire Cassidy
wiley +1 more source

