Results 101 to 110 of about 184,463 (305)
Advanced Science, EarlyView.Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang +13 more
wiley +1 more source
, 2002 Child abuse has been very much in the news recently. Each time a child dies because of it, there is much publicity, much media soul-searching, numerous pronouncements from spokespeople but there is little change.
Ritchie, Jane
core
The Role of Family in the Initiation and Enabling of Alcohol and Substance Abuse
Family is the basic unit of a nation, and the primary institution for knowledge and skill acquisition, and it further shapes individual attitudes, desires, and behavior, both in the right and negative manner. The family regarding the rising dependence on
KIPCHUMBA, HEATHER
core +2 more sources
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
The purpose of this paper is to describe and outline the growth of government guidance on child protection in England from 1974 to 2010. In the process it will be suggested that such analysis provides important insights into the changing nature of child ...
Parton, Nigel
core
, 2019 Background State child welfare agencies collect, store, and manage vast amounts of data. However, they often do not have the right data, or the data is problematic or difficult to inform strategies to improve services and system processes.
Moore, Andrew +6 more
core +1 more source
Advanced Science, EarlyView.Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan +8 more
wiley +1 more source
Online Journal of Health & Allied Sciences, 2020 Introduction: Every child had all the rights to a safe childhood and a life free from violence. The experience of child abuse and neglect infringe upon that right. An estimated 10–20% of adolescents globally experience mental health conditions, yet these
Gavishiddhayya Salimath, Sudha A Raddi
doaj
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source