Results 121 to 130 of about 937,564 (308)

Biomimetic Ru‐Mn Nanozyme with Cascade Catalytic Activity Attenuates Secondary Brain Injury in Intracerebral Hemorrhage

open access: yesAdvanced Science, EarlyView.
Ru–Mn composite nanozymes are engineered to mimic dual‐enzyme cascade catalysis, enabling efficient ROS clearance and neuroinflammation suppression. In collagenase‐ and autologous blood‐induced ICH mouse models, intranasal and intravenous administration reduced hematoma volume, preserved BBB integrity, and improved neurological recovery.
Zhongxin Duan   +8 more
wiley   +1 more source

The Status of Women in the South [PDF]

open access: yes, 2016
The southern United States is a dynamic and influential region marked by innovation and economic opportunities for women, yet also a region where inequalities persist and many women -- especially women of color and those who are immigrants -- face ...
Asha DuMonthier   +4 more
core  

Tailored Organogel Systems for Optimized Pesticide Delivery: Mechanistic Insights and Agricultural Applications

open access: yesAdvanced Science, EarlyView.
Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang   +6 more
wiley   +1 more source

Conditioning U.S. Security Assistance on Human Rights Practices [PDF]

open access: yes, 1982
In the United States, with its government of separated powers and functions, it is the executive branch, and in particular the Department of State, that bears responsibility for implementing legislation on foreign relations. The success of implementation
Cohen, Stephen B.
core   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

School bullying: children and adolescent norms, cultures and identity development

open access: yesFrontiers in Education
IntroductionSchool bullying arises from a system of peers who form bonds through the repeated victimization of others. This empirical research article examines the function of bullying within the context of children and adolescent norms and cultures ...
Zoe Moody   +3 more
doaj   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

open access: yesAdvanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian   +13 more
wiley   +1 more source

Asylum in Practice: Successes, Failures, and the Challenges Ahead [PDF]

open access: yes, 2000
The Workshop on Refugee and Asylum Policy in Practice in Europe and North America was organized to facilitate a transatlantic dialogue aimed at understanding just how well these asylum systems are balancing the dual goals.
Martin, Susan, Schoenholtz, Andrew I.
core   +1 more source

Neutrophil‐Driven Cascade‐Targeted Nanocarriers Restore Mitochondrial Homeostasis to Ameliorate Renal Ischemia–Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
A neutrophil‐mediated dual‐targeting liposome (NKN‐LNP) is developed to treat renal ischemia–reperfusion injury. The system enables spatiotemporally controlled delivery of NMN to injured tubules via MMP‐2/9 activation and KIM1 recognition, restoring mitochondrial function through NAD+‐SIRT3 signaling and preventing the transition from acute kidney ...
Hangbin Ma   +15 more
wiley   +1 more source

EXERCISE WITH BAD FAITH OF SUBJECTIVE CIVIL RIGHTS [PDF]

open access: yesChallenges of the Knowledge Society, 2012
The abuse of rights is qualified as civil offence and it may not be different from that of aquilian responsibility, the purpose of its sanction is to protect the victim and not to punish the author. In the Romanian legal doctrine, the abuse of rights was
NICOLAE GRADINARU
doaj  

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