Results 121 to 130 of about 80,200 (257)

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

open access: yesAdvanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi   +8 more
wiley   +1 more source

Precision Oncology via Radiotherapy‐Triggered Drug Delivery: Mechanisms, Molecular Engineering, and Clinical Translation

open access: yesAdvanced Science, EarlyView.
This review redefines radiotherapy‐triggered drug delivery systems through structural disassembly and molecular actuation, proposing a translation‐oriented framework for dose‐correlated activation to advance clinically integrated precision oncology. ABSTRACT Radiotherapy‐triggered drug delivery systems (RDDS) promise to integrate the spatial precision ...
Jianv Jiang   +3 more
wiley   +1 more source

Aby Warburg e Walter Benjamin. Il metodo della memoria

open access: yesAisthesis, 2012
Many words extracted from the electric-electronic dictionary could be useful to understand a nexus between Warburg and Benjamin. Memory as accumulator is the link that connects these two collectors –and coordinators- of impressions.
Guglielmo Bilancioni
doaj   +2 more sources

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

open access: yesAdvanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan   +13 more
wiley   +1 more source

Entre el nachleben y el paradigma indiciario: Carlo Ginzburg y el método warburgiano en la historia del arte

open access: yesHistoria y Sociedad, 2016
El presente artículo analiza la producción histórica de Carlos Ginzburg en la disciplina de la historia del arte y, en particular, sus relaciones teórico-metodológicas con la obra del historiador alemán Aby Warburg.
Federico Ardila Garcés
doaj  

Ex Libris Aby Warburg: Magic and Science

open access: yes, 2017
Bücher aus dem Besitz von Aby Warburg, Teil der Warburg Digital Library https://wdl.warburg.sas.ac.uk/islandora/object/islandora%3A3969 Die frühere digitale Sammlung hat keine eigene Seite mehr, die PDFs sind aber noch vom OPAC aus abrufbar.
Klaus Graf
core  

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai   +12 more
wiley   +1 more source

Profilo di un atlante: il cerchio e l'ellissi. Note sul "Bilderatlas" di Aby Warburg

open access: yes, 2004
According to the essay, with his ‘Mnemosyne Project’ (Bilderatlas, 1929) Aby Warburg renewed not only our way of understanding images, but also of reckoning with the weight of art-images (specially taken from the art of the Renaissance) in understanding ...
TAVANI, ELENA
core  

Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4‐Dependent Enhancer Activation

open access: yesAdvanced Science, EarlyView.
To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai   +4 more
wiley   +1 more source

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