Results 41 to 50 of about 2,572,717 (328)

AC Oscillation of a Spin Soliton Driven by a Constant Force

, 2020
The phenomena of AC oscillation generated by a DC drive, such as the famous Josephson AC effect in superconductors and Bloch oscillation in solid physics, are of great interest in physics.
Liu, J, Tang, Q., Wang, W., Yang, W-L, Yang, Z-Y, Zhao, L-C   +5 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

AC-drive System of the Intercity EMUs

机车电传动, 2015
The design principle of the AC drive system in the intercity EMUs was expounded, emphasis on the key technology such the structure, the working principle and the technical characteristics, which pointed out that the integrative convertor of the AC drive ...
ZHANG Zhibing, RONG Zhilin, YAO Zhonghong   +2 more
doaj  

Design, Implementation and Control of a SiC-Based T5MLC Induction Drive System

IEEE Access, 2020
This paper presents and evaluate a prototype of an advanced topology of five-level T-type MLC, namely “T5MLC”, implemented within a complete AC induction drive.
Aboubakr Salem
doaj   +1 more source

Dielectric nonlinearity of relaxor ferroelectric ceramics at low ac drives

, 2000
Dielectric nonlinear response of (PbMg$_{1/3}$Nb$_{2/3}$O$_3$)$_{0.9}$(PbTiO$_3$)$_{0.1}$ (0.9PMN-0.1PT) relaxor ceramics was investigated under different ac drive voltages. It was observed that: (i) the dielectric permittivity is independent on ac field
Bing-Lin Gu, Bokov V A, Chen J, Colla E V, Cross L E, Glazounov A E, Glazounov A E, Gui H, Liu Xi, Newnham R E, Pan X Q, Randall C A, Shrout T R, Smolenski G A, Swartz S L, Tan Q, Uchino K, Xi Liu, Xiao-Wen Zhang, Zhi-Rong Liu   +19 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Controllable diffusion of cold atoms in a harmonically driven and tilted optical lattice: Decoherence by spontaneous emission

, 2008
We have studied some transport properties of cold atoms in an accelerated optical lattice in the presence of decohering effects due to spontaneous emission. One new feature added is the effect of an external AC drive.
Bloch F, Bloch I Dalibard J Zwerger W, Eckardt A, Jessen P S, Linger H Sias C Ciampini D Singh Y Zenesini A Morsch O Arimondo E, Navinder Singh, Zhao X-G   +6 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source