Results 41 to 50 of about 576,811 (251)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Analysis of passive interference on radio station from AC UHV power

E3S Web of Conferences, 2018
The problems of Electromagnetic Interference in Airborne Intelligence Radar Stations near the AC UHV Transmission Lines is researched in this paper, which is mainly passive interference. And then analyzed the passive interference of AC UHV lines.
GAN Zheyuan, ZHANG Jiangong, ZHAO Jun, Lu ying   +3 more
doaj   +1 more source

Corrosion Behavior of X65 and X80 Pipeline Steels under AC Interference Condition in High pH Solution

International Journal of Electrochemical Science, 2018
The corrosion behavior of X65 and X80 pipeline steels under AC interference in high pH solution was investigated by potentiodynamic polarization curve, open circuit potential, Mott-Schottky curve and immersion test.
Min Zhu, Yongfeng Yuan, Simin Yin, Shaoyi Guo   +3 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Influence of alternating current on corrosion behavior of X100 steel in Golmud soil simulated solution with different pH

International Journal of Electrochemical Science, 2020
The alternating current (AC) corrosion behavior of X100 steel was studied in Golmud soil simulated solution with different pH using electrochemical measurement, immersion test and surface analysis technology.
Jinlin Yang, Min Zhu, Zhongping Le, Baozhu Zhao, Jun Ma, Yongfeng Yuan, Shaoyi Guo   +6 more
doaj   +1 more source

Study on the Interference Law of AC Transmission Lines on the Cathodic Protection Potential of Long-Distance Transmission Pipelines

Magnetochemistry, 2023
Through inductive coupling, AC transmission lines can generate large amounts of voltage to buried oil and gas pipelines in areas with common corridors, posing a threat to the cathodic protection effect of pipelines. Therefore, this paper investigates the
Boyang Zhang, Lin Li, Yansong Zhang, Jielin Wang   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Protection Criteria of Cathodically Protected Pipelines Under AC Interference

Corrosion and Materials Degradation
Carbon steel structures employed to convey hydrocarbons and other dangerous fluids, such as oil or flammable liquids, are equipped with degradation prevention systems, which typically consist of a cathodic protection (CP) system combined with an external
Luca Paterlini, Andrea Marinelli, Andrea Brenna, Marco Ormellese   +3 more
doaj   +1 more source

Stress corrosion cracking behavior of X80 pipeline steel under alternating current, Desulfovibrio desulfurican and cathodic protection potential

Journal of Materials Research and Technology, 2023
The stress corrosion cracking (SCC) behavior of X80 pipeline steel under Desulfovibrio desulfurican (D. desulfurican), alternating current (AC) and cathodic protection (CP) was studied by the constant load tests and slow strain rate tensile (SSRT) test ...
Qi Fu, Qingyu Qin, Boxin Wei, Jin Xu, Changkun Yu, Cheng Sun   +5 more
doaj   +1 more source