Results 71 to 80 of about 3,387,209 (298)

A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers. [PDF]

PLoS ONE, 2014
HIV replication is only partially controlled by HIV-specific activated effector T cells in chronic HIV infection and strategies are warranted to improve their efficacy.
Andreas Lind, Kristin Brekke, Frank Olav Pettersen, Tom Eirik Mollnes, Marius Trøseid, Dag Kvale   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Design and Control of Advanced Uninterruptible Power Supplies With SiC MOSFETs for Enhanced Performance and Efficiency

IEEE Access
This paper proposes a high-performance high-efficiency single-phase uninterruptible power supply (UPS), which uses totem pole power factor correction in AC/DC stage and three-level T-type inverter in DC/AC stage.
Quoc Nam Trinh, Thanh Hai Nguyen
doaj   +1 more source

Butterfly optimizer-assisted optimal integration of REDG units in hybrid AC/DC distribution micro-grids based on minimum operational area

Journal of Electrical Systems and Information Technology, 2021
This paper presents the impact of optimal location and sizing of renewable and non-renewable-based distributed generators in the AC/DC micro-grid system using the latest optimizer called butterfly optimization algorithm with an aim to minimize power loss.
Satish Kumar Injeti
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

AC loss measurements with a cryocooled sample [PDF]

IEEE Transactions on Appiled Superconductivity, 2001
A new cryostat cooled by a closed-cycle Cryomech GB-37 cryocooler for superconductor measurements at temperatures down to 20 K is described. The sample is conductively coupled to the cold stage so as to minimize vibration and thermal stresses. AC losses have been measured calorimetrically in several high-temperature superconductor coils that have been ...
S.W. Schwenterly, J.A. Demko, J.W. Lue, M.S. Walker, C.T. Reis, D.W. Hazelton, null Xin Shi, M.T. Gardner   +7 more
openaire   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Effects of a novel peptide Ac-SDKP in radiation-induced coronary endothelial damage and resting myocardial blood flow

Cardio-Oncology, 2018
Background Cancer survivors treated with thoracic ionizing radiation are at higher risk of premature death due to myocardial ischemia. No therapy is currently available to prevent or mitigate these effects.
Umesh C. Sharma, Swati D. Sonkawade, Andrew Baird, Min Chen, Shirley Xu, Sandra Sexton, Anurag K. Singh, Adrienne Groman, Steven G. Turowski, Joseph A. Spernyak, Supriya D. Mahajan, Saraswati Pokharel   +11 more
doaj   +1 more source