Results 51 to 60 of about 330,244 (267)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
A Comprehensive Loss Model and Comparison of AC and DC Boost Converters
Energies, 2021 DC microgrids have become a prevalent topic in research in part due to the expected superior efficiency of DC/DC converters compared to their AC/DC counterparts.
Daniel L. Gerber +6 more
doaj +1 more source
Current distribution and AC losses in twisted multifilamentary AC superconductors [PDF]
IEEE Transactions on Magnetics, 1989 The development of AC superconductors has led to multifilamentary wires having a highly resistive matrix material and a small twist pitch and filament diameter. A numerical one-dimensional model is presented which enables the authors to calculate the current distribution as well as the magnetization and transport current loss in a current-carrying AC ...
Roovers, A.J.M., van de Klundert, L.J.M.
openaire +2 more sources
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A parameter for IL-10 and TGF-ß mediated regulation of HIV-1 specific T cell activation provides novel information and relates to progression markers. [PDF]
PLoS ONE, 2014 HIV replication is only partially controlled by HIV-specific activated effector T cells in chronic HIV infection and strategies are warranted to improve their efficacy.
Andreas Lind +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
A distinct method to eliminate the induced voltage in AC loss determination without phase control
AIP Advances, 2020 AC loss is often considered one of the most important design parameters that guide the fabrication of superconducting devices. Thus, the electrometric method to determine AC loss of superconductors is crucial.
Liuyang Shen +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
IEEE AccessThis paper proposes a high-performance high-efficiency single-phase uninterruptible power supply (UPS), which uses totem pole power factor correction in AC/DC stage and three-level T-type inverter in DC/AC stage.
Quoc Nam Trinh, Thanh Hai Nguyen
doaj +1 more source