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TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao   +12 more
wiley   +1 more source
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External engagement of academics

2022
Abstract:Over the past 40 years, there has been a continued debate about the role of universities indriving economic growth and the extent to which collaboration between the academic andnon-academic sectors is a fundamental enabler of this role. In this context the engagement ofindividual academics with external organisations is considered an important
  +5 more sources

What is Academic Engagement? Developing and Testing an Integrated Academic Engagement Framework

Academy of Management Proceedings, 2015
Academic engagement is a topic with great appeal because of its demonstrated positive relationship to a number of academic outcomes (grades, mastery of material, overcoming impediments, etc.).
Danielle Beu Ammeter   +3 more
openaire   +1 more source

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