Results 51 to 60 of about 3,188,000 (341)

Risk as an Approach to Regulatory Governance: An Evidence Synthesis and Research Agenda

SAGE Open, 2021
Governments around the world have begun to develop and implement risk governance and risk-based regulation and are often inspired by the insights from risk studies in doing so.
Jeroen van der Heijden
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Governance of a complex system: water [PDF]

, 2014
This paper sets out a complex adaptive systems view of water governance. Overview Fresh water is a life - enabling resource as well as the source of spiritual, social and economic wellbeing and development.
Elizabeth Eppel
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Extent of Application of Good Governance at Qatar University from the Point of View of Heads of Academic Departments and Faculty Members

دراسات: العلوم التربوية, 2021
This study aims to identify the degree of application of good governance at Qatar University from the point of view of the heads of academic departments and faculty members. Its sample consisted of (318) faculty members and heads of academic departments
Hamda Al- Saa’deyah
doaj  

The Academic Research Consortium Governance Charter

JACC: Cardiovascular Interventions, 2011
Evaluation of new medical devices and demonstration of their conformity to essential principles of safety and effectiveness frequently require clinical trials in human subjects. For many cardiovascular devices, in particular implantable or invasive devices, ethical, clinical, and ...
Krucoff, Mitchell W., Mehran, Roxana, van Es, Gerrit-Anne, Boam, Ashley B., Cutlip, Donald E.   +4 more
openaire   +2 more sources

Academic freedom in Europe: reviewing UNESCO’s recommendation [PDF]

, 2009
This paper examines the compliance of universities in the European Union with the UNESCO Recommendation concerning the Status of Higher–Education Teaching Personnel, which deals primarily with protection for academic freedom.
BARNETT R., BEITER K., BISSELL C., EISEMANN P., FINKIN M., LIEBERWITZ R., MACHLUP F., MARKS S., MATSUURA K., MIYASAKA M., OLSEN J., O’CONNELL M., O’NEIL R., PAULSEN F., RENAUT A., ROVERSI-MONACO F., RUEGG W., SANZ N., SYMONIDES J., Terence Karran, WIERUSZOWSKI H.   +20 more
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Blockchain-Enabled Corporate Governance and Regulation

International Journal of Financial Studies, 2020
There is considerable hype about blockchain in almost every industry, including finance, with significant investments globally. We conduct a systematic review of 851 records and construct a final article sample of 183 for the sample period 2012 to 2020 ...
Dulani Jayasuriya Daluwathumullagamage, Alexandra Sims   +1 more
doaj   +1 more source