Results 241 to 250 of about 3,769,352 (358)

Making MALDI-TOF MS for entomological parameters accessible: A practical guide for in-house library creation. [PDF]

PLoS One
Karisa J, Tuwei M, Ominde K, Bartilol B, Ondieki Z, Musani H, Rono M, Mbogo C, Bejon P, Mwangangi J, Wanjiku C, Maia M.   +11 more
europepmc   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Barcode-free hit discovery from massive libraries enabled by automated small molecule structure annotation. [PDF]

Nat Commun
van der Nol E, Haupt NA, Gao QQ, Smit BAM, Hoffmann MA, Engler-Lukajewski M, Ludwig M, McKenna S, Mata JM, Béquignon OJM, van Westen G, Wendel TJ, Noordermeer SM, Böcker S, Pomplun S.   +14 more
europepmc   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Diversity as the Fuel of Theory: Demographic Biases in CHILDES and Its Commentaries. [PDF]

Dev Sci
Scaff C, Loukatou G, Cristia A, Havron N.   +3 more
europepmc   +1 more source

How Important is Data Curation? Gaps and Opportunities for Academic Libraries

, 2018
Lisa Johnston, Jake Carlson, Cynthia Hudson‐Vitale, H.J. Imker, Wendy Kozlowski, Robert Olendorf, Claire Stewart   +6 more
openalex   +2 more sources

Deacetylation of ACLY Mediates RNA M6A‐Modification of NOXA and Promotes Chemoresistance of Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the deacetylation of ACLY at K978 acts as a novel risk in colorectal cancer chemoresistance. The deacetylation of K978 induces ACLY relocation to the nucleus and promotes its binding to RBM15, a m6A methylation modification “writer”.
Jun Wen, Mengqin Shen, Haitao Zhao, Liu Liu, Qian Hua, Xiaoping Zhao, Jianjun Liu, Haizhong Feng, Gang Huang   +8 more
wiley   +1 more source

Reformation of science publishing: the Stockholm Declaration. [PDF]

R Soc Open Sci
Sabel B, Larhammar D.
europepmc   +1 more source

Assessing the effectiveness of an e-resource marketing campaign in a Hong Kong academic library

, 2017
Chloe Lei, Jennifer Gu
openalex   +1 more source