Results 281 to 290 of about 466,974 (354)

Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform

Advanced Science, EarlyView.
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng, Jiahao Lin, Qiushuang Zhang, Xiangdong Zhang, Yicong Dai, Jinghong Li   +5 more
wiley   +1 more source

Spatial Dynamics of Student Conflicts in Spanish Higher Education: Gender and Academic Discipline Differences in Campus Spaces. [PDF]

Behav Sci (Basel)
Rojas-Ruiz G, Mingorance-Estrada ÁC, Alemany-Arrebola I.   +2 more
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Book Club at a medical school in the Sertão Region of Rio Grande do Norte State, Brazil. [PDF]

J Med Libr Assoc
Sampaio AL, Silva Á, Limão Y, Bezerra L, Braz J.   +4 more
europepmc   +1 more source

Security and the Administration of Manuscript Holdings at Southern Academic Libraries: Part I: Administration, Staffing, and Physical Security

, 1980
Katherine F. Martin
openalex   +1 more source

The Role of Academic Libraries in Quality Assurance in Higher Education: A Comprehensive Literature Review

Kh. Nanda Singh, Prof. Th. Madhuri Devi, Ningolleima Chanu Thounaojam, Thokchom Lenin Singh
openalex   +1 more source

High‐Power Terahertz Emission from Picosecond Nano‐Plasma Switching Driven by Secondary Electron Emission Avalanche

Advanced Science, EarlyView.
A nano‐plasma device enables watt‐level on‐chip THz generation through picosecond switching triggered by secondary electron emission avalanche. An ultra‐dense electron sheet initiates nano‐plasma formation within a ∼100 nm gap, driving rapid energy release into an integrated resonator.
Guangyu Sun, Mohammad Rezaei, Yuheng Hu, Guan‐Jun Zhang, Elison Matioli   +4 more
wiley   +1 more source

Infusing Artificial Intelligence For Transformative Impact In Academic Libraries: A Technical Perspective

Dr. Gaurav Kumar Jaiswal
openalex   +1 more source

Cotton Recruits Soil‐Derived Delftia tsuruhatensis to Suppress Aphid Detoxification Via Salicylic Acid‐Mediated Defense

Advanced Science, EarlyView.
This study systematically reveals a complex interactive network involving plants, microbes, and insects, elucidating the ecological and molecular mechanisms by which cotton enhances its resistance to aphids through the active recruitment of the beneficial soil bacterium Delftia tsuruhatensis.
Hui Xue, Fengchao Diao, Qiqing Yu, Xiangzhen Zhu, Tingfang Zhong, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Junyu Luo, Jinjie Cui, Xueke Gao   +11 more
wiley   +1 more source

Idler Compounds: A Simple Protocol for Openly Sharing Fridge Contents for Cross-Screening. [PDF]

J Med Chem
Isaksson R, Carter EM, Hind CK, Sutton JM, Rudgyard H, Roberts AH, Moon CW, Wang Y, Todd Group Researchers, Codony S, Martínez AL, Bacon J, Todd MH.   +12 more
europepmc   +1 more source