Worldwide distribution of genotypes in Acanthamoeba keratitis : a systematic review [PDF]
, 2020 Acanthamoeba spp. are among the most prevalent protozoa distributed in the world, causing diseases as Acanthamoeba keratitis, which is a painful and severe sight threatening corneal disease that in some cases can cause even blindness.
Diehl, Maria Luísa Nunes
core
Evolutionary Dynamics of Giant Viruses and their Virophages [PDF]
arXiv, 2013 Giant viruses contain large genomes, encode many proteins atypical for viruses, replicate in large viral factories, and tend to infect protists. The giant virus replication factories can in turn be infected by so called virophages, which are smaller viruses that negatively impact giant virus replication.
arxiv
British Journal of Ophthalmology, 2019 Aims To test the hypothesis that Acanthamoeba keratitis (AK) outcomes differ for different topical antiamoebic therapies (AAT) and to provide the detailed patient outcome data. Methods A retrospective cohort study of 227 patients developing AK between 25
V. Papa +4 more
semanticscholar +1 more source
Azole Antifungal Agents To Treat the Human Pathogens Acanthamoeba castellanii and Acanthamoeba polyphaga through Inhibition of Sterol 14α-Demethylase (CYP51) [PDF]
, 2015 Herein, we have investigated the amebicidal activities of the pharmaceutical triazole CYP51 inhibitors fluconazole, itraconazole, and voriconazole against Acanthamoeba castellanii and Acanthamoeba polyphaga and assess their potential as therapeutic ...
Andrew G. S. Warrilow +7 more
core +1 more source
Notes from the Field: Acanthamoeba Keratitis Cases — Iowa, 2002–2017
MMWR. Morbidity and mortality weekly report, 2019 Acanthamoeba is a ubiquitous protozoan that feeds on bacteria and yeast. Because of its ability to encyst in extreme environmental conditions, the organism is difficult to kill.
Brittni A Scruggs +3 more
semanticscholar +1 more source
Zeolitic Imidazolate Framework-8 offers an anti-inflammatory and antifungal method in the treatment of Aspergillus fungus keratitis in vitro and in vivo [PDF]
arXivBackground: Fungal keratitis is a serious blinding eye disease. Traditional drugs used to treat fungal keratitis commonly have the disadvantages of low bioavailability, poor dispersion, and limited permeability. Purpose: To develop a new method for the treatment of fungal keratitis with improved bioavailability, dispersion, and permeability.
arxiv
Acanthamoeba keratitis — The quest for a better prognosis [PDF]
, 1988 Linda Ficker
openalex +1 more source
Acanthamoeba Keratitis: The Emerging Vision-Threatening Corneal Disease [PDF]
, 2016 Some Acanthamoeba species are distributed in natural and man-made environments, in a wide range of soil and aquatic habitats, also in clinical settings.
Chomicz, Lidia +3 more
core +2 more sources
Acanthamoeba keratitis: a sobering case and a promising new treatment [PDF]
, 1994 Trevor Gray +3 more
openalex +1 more source
ZIF-90 treats fungal keratitis by promoting macrophage apoptosis and inhibiting inflammatory response [PDF]
arXivFungal keratitis is a severe vision-threatening corneal infection with a prognosis influenced by fungal virulence and the host's immune defense mechanisms. The immune system, through its regulation of the inflammatory response, ensures cells and tissues can effectively activate defense mechanisms in response to infection and injury.
arxiv